Ignite Creation Date:
2024-05-05 @ 9:16 PM
Last Modification Date:
2024-10-26 @ 10:01 AM
Study NCT ID:
NCT00844974
Status:
COMPLETED
Last Update Posted:
2013-11-18
First Post:
2008-05-08
Brief Title:
Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder Depressed Type Prevalence and Improvement With Treatment of Depressive Symptoms
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Cognitive Deficits in Major Depressive Disorder and Bipolar Disorder Depressed Type Prevalence and Symptoms With Treating of Depressive Symptoms
Status:
COMPLETED
Status Verified Date:
2013-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this research study is to learn more about cognitive deficits in people with certain mood disorders The mood disorders are Major Depressive Disorder MDD and Bipolar disorder depressed type
Cognitive deficits are problems with things like thinking and memory People with cognitive deficits may have problems concentrating and paying attention When talking they may have trouble recalling a word they want to say They may think slowly and have problems remembering things These deficits can affect an individuals ability to work and function socially Cognitive deficits that occur with depression may increase the risk of a relapse of major depressive disorder
We want to study the course of cognitive impairment in subjects as they are receiving treatment for their depression We want to find out if their cognitive deficits get better worse or stay the same
We also want to learn more about a stress hormone called cortisol that is produced in the body We want to study the relationship between cortisol and cognitive impairment Recent research has shown that cognitive impairment may be more severe in people who have high levels of cortisol in their blood
We will also measure the levels of a protein in your blood called brain-derived neurotrophic factor BDNF BDNF helps the growth of new brain cells It appears that the growth of new brain cells lessens when people are depressed Treatment with antidepressant medications may cause BDNF levels to increase and return to normal We are interested in studying the relationship between BDNF levels and cognitive impairment throughout treatment
Cognitive deficits are problems with things like thinking and memory People with cognitive deficits may have problems concentrating and paying attention When talking they may have trouble recalling a word they want to say They may think slowly and have problems remembering things These deficits can affect an individuals ability to work and function socially Cognitive deficits that occur with depression may increase the risk of a relapse of major depressive disorder
We want to study the course of cognitive impairment in subjects as they are receiving treatment for their depression We want to find out if their cognitive deficits get better worse or stay the same
We also want to learn more about a stress hormone called cortisol that is produced in the body We want to study the relationship between cortisol and cognitive impairment Recent research has shown that cognitive impairment may be more severe in people who have high levels of cortisol in their blood
We will also measure the levels of a protein in your blood called brain-derived neurotrophic factor BDNF BDNF helps the growth of new brain cells It appears that the growth of new brain cells lessens when people are depressed Treatment with antidepressant medications may cause BDNF levels to increase and return to normal We are interested in studying the relationship between BDNF levels and cognitive impairment throughout treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None