Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00029978
Status:
COMPLETED
Last Update Posted:
2006-08-18
First Post:
2002-01-29
Brief Title:
Transfer of Neural Energy Between Humans
Sponsor:
National Center for Complementary and Integrative Health NCCIH
Organization:
National Center for Complementary and Integrative Health NCCIH
Study Overview
Official Title:
Transfer of Neural Energy Between Human Subjects
Status:
COMPLETED
Status Verified Date:
2006-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether visual evoked potentials generated in one human brain by photostimulation can generate a correlated EEG signal in the brain of another human subject who is located at a distance and who is not visually stimulated
Detailed Description:
This study will attempt to replicate findings suggesting that visual evoked potentials generated in one human brain Subject A by photostimulation can generate a correlated EEG signal in the brain of another human subject subject B who is located at a distance 145 meters and who is not visually stimulated
This project will occur in three stages First we will identify pairs of subjects who have cross-correlated evoked potentials during photostimulation to Subject A at the p 01 level of significance If no pairs can be identified we will continue to enroll and test up to 50 pairs of subjects If pairs of subjects that demonstrate the phenomenon cannot be identified using this p value by the end of the project time line we will reject the hypothesis that remote transfer of neural energy occurs and report failure to replicate the original study If we detect greater than or equal to 5 pairs of subjects who meet the criteria we will attempt to replicate in those pairs using a higher criteria of p 001 If Grinberg-Zylberbaum et als experiment can be replicated at both stages the project team will go to stage 3 to investigate the same phenomenon in the identified pairs of human subjects using functional magnetic resonance imaging fMRI as a second independent neurophysiological measure of transfer of information between two human brains We will record fMRIs occipital temporal frontal and parietal in the remote individual while their counterpart located in a separate chamber is receiving light stimulation in an on-off pattern We will determine if there are statistically significant differences in digitized fMRI during lights on vs lights off conditions The main outcome measures for this project will be the binary yes-no output from statistical analysis using cross-correlational and z-score testing for the detection of a transferred evoked signal in both EEG and fMRI experiments in Subject B Appropriate controls will be used If replicated this study will provide a useful technology and method to quantitatively investigate the characteristics and neural mechanisms of remote effects of mental events Such experimental methods will assist in the investigation of basic mechanisms involved in mind-body medicine
This project will occur in three stages First we will identify pairs of subjects who have cross-correlated evoked potentials during photostimulation to Subject A at the p 01 level of significance If no pairs can be identified we will continue to enroll and test up to 50 pairs of subjects If pairs of subjects that demonstrate the phenomenon cannot be identified using this p value by the end of the project time line we will reject the hypothesis that remote transfer of neural energy occurs and report failure to replicate the original study If we detect greater than or equal to 5 pairs of subjects who meet the criteria we will attempt to replicate in those pairs using a higher criteria of p 001 If Grinberg-Zylberbaum et als experiment can be replicated at both stages the project team will go to stage 3 to investigate the same phenomenon in the identified pairs of human subjects using functional magnetic resonance imaging fMRI as a second independent neurophysiological measure of transfer of information between two human brains We will record fMRIs occipital temporal frontal and parietal in the remote individual while their counterpart located in a separate chamber is receiving light stimulation in an on-off pattern We will determine if there are statistically significant differences in digitized fMRI during lights on vs lights off conditions The main outcome measures for this project will be the binary yes-no output from statistical analysis using cross-correlational and z-score testing for the detection of a transferred evoked signal in both EEG and fMRI experiments in Subject B Appropriate controls will be used If replicated this study will provide a useful technology and method to quantitatively investigate the characteristics and neural mechanisms of remote effects of mental events Such experimental methods will assist in the investigation of basic mechanisms involved in mind-body medicine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None