Ignite Creation Date:
2025-12-24 @ 10:47 PM
Ignite Modification Date:
2025-12-31 @ 4:31 PM
Study NCT ID:
NCT07065669
Status:
RECRUITING
Last Update Posted:
2025-07-15
First Post:
2025-06-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation
Sponsor:
University of California, San Francisco
Organization:
Study Overview
Official Title:
Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation
Status:
RECRUITING
Status Verified Date:
2025-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents.
The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD.
Participants will:
* visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments
* have a brain MRI scan before TMS treatments begins and after finishing all TMS
* complete questionnaires and report changes in behavior and physical symptoms
The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD.
Participants will:
* visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments
* have a brain MRI scan before TMS treatments begins and after finishing all TMS
* complete questionnaires and report changes in behavior and physical symptoms
Detailed Description:
This study's primary goal is to examine whether treatment with two forms of transcranial magnetic stimulation (TMS) called theta burst stimulation (TBS) show acceptable tolerability, safety, and preliminary signals of efficacy for adolescents with Obsessive Compulsive Disorder (OCD) that has not responded satisfactorily to 1st line treatments. While TMS is FDA-approved for OCD in adults, data on TMS in youth with OCD is limited. Results will inform on how suitable TMS treatment is for adolescents with OCD, and guide future, larger studies.
The study is considered a randomized, single blind, clinical trial.
The design of the study is a two-group parallel comparative study of two different TMS stimulation sites, the orbito-frontal cortex (OFC) and the dorsal medial prefrontal cortex (dmPFC).
Model description: both groups will receive active TMS treatment sessions in clinic every weekday for 3 consecutive weeks (15 days). During each TMS session, participants in both groups will receive 3 TMS stimulations separated by a rest period, for a total of 45 individual TMS treatments. Study participants will receive TMS to only their assigned stimulation site.
Number of arms: there are two treatment arms based on assigned treatment site, an OFC arm and a dmPFC arm.
Masking: an independent evaluator will be masked to treatment arm assignment and adverse events. All other study personnel will not be masked.
Allocation: participants will be randomly assigned to group according to a computer-generated assignment schedule.
Enrollment: total planned enrollment is 30 eligible participants who are randomized.
Arm Information:
Arm titles-- orbitofrontal cortex (OFC) and dorsal medial prefrontal cortex (dmPFC) Arm types: the dmPFC arm is considered the intervention arm; the OFC arm is considered the active comparator arm.
Interventions:
Intervention type: Device (both arms)
Intervention name(s):
OFC - continuous theta burst stimulation (cTBS) dmPFC - intermittent theta burst stimulation (iTBS)
Intervention description:
OFC - three stimulations per day of 1,800 pulses/stimulation cTBS for 15 days dmPFC - three stimulations per day of 1,800 pulses/session iTBS for 15 days
The study is considered a randomized, single blind, clinical trial.
The design of the study is a two-group parallel comparative study of two different TMS stimulation sites, the orbito-frontal cortex (OFC) and the dorsal medial prefrontal cortex (dmPFC).
Model description: both groups will receive active TMS treatment sessions in clinic every weekday for 3 consecutive weeks (15 days). During each TMS session, participants in both groups will receive 3 TMS stimulations separated by a rest period, for a total of 45 individual TMS treatments. Study participants will receive TMS to only their assigned stimulation site.
Number of arms: there are two treatment arms based on assigned treatment site, an OFC arm and a dmPFC arm.
Masking: an independent evaluator will be masked to treatment arm assignment and adverse events. All other study personnel will not be masked.
Allocation: participants will be randomly assigned to group according to a computer-generated assignment schedule.
Enrollment: total planned enrollment is 30 eligible participants who are randomized.
Arm Information:
Arm titles-- orbitofrontal cortex (OFC) and dorsal medial prefrontal cortex (dmPFC) Arm types: the dmPFC arm is considered the intervention arm; the OFC arm is considered the active comparator arm.
Interventions:
Intervention type: Device (both arms)
Intervention name(s):
OFC - continuous theta burst stimulation (cTBS) dmPFC - intermittent theta burst stimulation (iTBS)
Intervention description:
OFC - three stimulations per day of 1,800 pulses/stimulation cTBS for 15 days dmPFC - three stimulations per day of 1,800 pulses/session iTBS for 15 days
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
True
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: