Ignite Creation Date:
2024-05-05 @ 9:13 PM
Last Modification Date:
2024-10-26 @ 10:01 AM
Study NCT ID:
NCT00849407
Status:
UNKNOWN
Last Update Posted:
2019-03-07
First Post:
2009-02-20
Brief Title:
Genetic Risk Factors and Acquired Oncogenic Mutations of Melanoma
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Genetic Risk Factors and Acquired Oncogenic Mutations of Melanoma
Status:
UNKNOWN
Status Verified Date:
2019-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
M3
Brief Summary:
Though it is generally accepted that exposure to sunlight is a major causative factor for skin cancer the risk for developing melanoma is not directly linked to sun exposure such as in non-melanoma skin cancer Therefore a dual pathway has been proposed distinguishing melanoma that develops on skin that is chronically exposed to sunlight from those that occur on skin that is normally protected The risk for each type of melanoma is believed to be determined in part by genetic factors To define these markers reproducibly the investigators plan to establish a large cohort with comprehensive information regarding sun sensitivity skin type history of experienced sun exposure skin pigmentation phenotypes total number of nevi and other types of skin tumors in a central European population The investigators will obtain blood from all participants for DNA as well as serum analyses Based on the finding that genetic variants of the melanocortin-1 receptor MC1R gene associated with red hair and fair skin have been shown to be associated with increased risk for melanoma particularly those harboring BRAF mutations the investigators will now focus on the study of recently discovered genetic variants associated with pigmentation Furthermore the investigators will study the relation of these variants with oncogenic mutations of melanoma in BRAF RAS and c-Kit The study of other genetic variants will follow once a sufficiently large cohort has been established to reveal an independent genetic risk factor in a multivariate analysis including potential covariates as mentioned above The identification of genetic risk factors for melanoma will not only help identify individuals with increased risk but also improve our understanding of the molecular background of the development of melanoma
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None