Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00026728
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-11-14
Brief Title:
Seroprevalence of Kaposis Sarcoma Herpes Virus in the United States
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Seroprevalence of Kaposis Sarcoma Herpesvirus in the United States
Status:
COMPLETED
Status Verified Date:
2005-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate patterns of Kaposis sarcoma herpes virus KSHV in the United States and its potential impact on the US population KSHV is a newly discovered virus that is strongly associated with Kaposis sarcoma and primary effusion lymphoma The high prevalence of KS and KSHV among HIV-infected homosexual men suggests sexual contact as a primary mode of transmission Reports of non-sexual transmission in parts of Africa and the Mediterranean where Kaposis sarcoma is endemic and the identification of viral DNA in saliva and other bodily fluids however indicate the virus is also transmitted non-sexually This study will
Compare the prevalence of KSHV among different demographic groups in the United States
Examine the association between KSHV and high risk behaviors such as drug use marijuana and cocaine sexual behavior age at first sexual intercourse and number of sexual partners and medical risk factors herpes simplex virus II hepatitis B and hepatitis C
Estimate the prevalence of KSHV in the United States
Data and blood samples for the study will be taken from the NHANES III survey NHANES is a program of periodic surveys conducted by the Centers for Disease Control and Preventions National Center for Health Statistics The survey is designed to provide national estimates of health status for the United States non-institutionalized civilian population by means of household interviews standardized physical examinations and blood sample collection and testing NHANES III-the seventh in a series of national examination studies-was conducted from 1988 to 1994
This study will use the HANES data to identify risks associated with a KSHV-positive blood test in the survey population The study plans to include all 19754 participants 67 of the 29314 participants originally examined for whom blood samples were collected and remain available
Compare the prevalence of KSHV among different demographic groups in the United States
Examine the association between KSHV and high risk behaviors such as drug use marijuana and cocaine sexual behavior age at first sexual intercourse and number of sexual partners and medical risk factors herpes simplex virus II hepatitis B and hepatitis C
Estimate the prevalence of KSHV in the United States
Data and blood samples for the study will be taken from the NHANES III survey NHANES is a program of periodic surveys conducted by the Centers for Disease Control and Preventions National Center for Health Statistics The survey is designed to provide national estimates of health status for the United States non-institutionalized civilian population by means of household interviews standardized physical examinations and blood sample collection and testing NHANES III-the seventh in a series of national examination studies-was conducted from 1988 to 1994
This study will use the HANES data to identify risks associated with a KSHV-positive blood test in the survey population The study plans to include all 19754 participants 67 of the 29314 participants originally examined for whom blood samples were collected and remain available
Detailed Description:
Kaposi sarcoma herpesvirus KSHV is the viral cause of Kaposi sarcoma Although infection with this virus appears to be uncommon in the United States the prevalence in the general population in uncertain and routes for transmission are poorly characterized This study makes use of questionnaire data and serum specimens obtained in the third National Health and Nutrition Survey NHAnes III Sera from 18168 individuals in this study were tested for antibodies to the KSHV proteins K81 and LANA We will use these measurements to estimate KSHV seroprevalence for the overall US general population and for demographic subgroups To characterize potential transmission routes we will also examine whether KSHV seroprevalence is related to sexual activity and exposures to blood as indicated by responses to questionnaire items and previous NHANES III measurements of markers of relevant viral infections
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-C-0073 | None | None | None |