Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00028184
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-12-17
Brief Title:
Role of the Intact Hemisphere in Recovery of Motor Function After Stroke
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Role of the Intact Hemisphere in Recovery of Motor Function After Stroke
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to better understand the role of the motor part of the brain in the recovery of motor function after stroke The motor deficits that follow a stroke are compensated for over several months It has been proposed that the ipsilateral motor cortex mediates these recovery processes The results of this study will provide fundamental information on the role of ipsilateral M1 in recovery of motor function after chronic stroke
A general patient evaluation will determine the location of the lesion site and assess the degree of impairment in motor and global cognitive functioning An assessment of motor function will also be performed Patients will be divided into two groups well and poorly recovered An MRI magnetic resonance imaging scan may also be done if one has not been performed in the past 6 months
Two main procedures will be performed transcranial magnetic stimulation TMS and test of motor performance In the first procedure a metal coil surrounded by a plastic mold will be placed on the head and electrical current will be pulsed through it The electrical muscle activity will be recorded through these electrodes with a computer The second procedure involves a reaction time test The task will consist of reacting to a visual stimulus by performing a voluntary movement TMS pulses will be given before each movement This is done to determine whether this type of stimulation interferes with reaction time which would indicated that it interferes with the brain centers executing the reaction to the visual Go-signal
Patients with single ischemic hemispheric lesions at least 12 months after the stroke who initially had a severe paralysis of the arm will be recruited for the study Healthy normal volunteers will also be included in the study A special effort will be made to increase the participation of women and diverse racial groups
A general patient evaluation will determine the location of the lesion site and assess the degree of impairment in motor and global cognitive functioning An assessment of motor function will also be performed Patients will be divided into two groups well and poorly recovered An MRI magnetic resonance imaging scan may also be done if one has not been performed in the past 6 months
Two main procedures will be performed transcranial magnetic stimulation TMS and test of motor performance In the first procedure a metal coil surrounded by a plastic mold will be placed on the head and electrical current will be pulsed through it The electrical muscle activity will be recorded through these electrodes with a computer The second procedure involves a reaction time test The task will consist of reacting to a visual stimulus by performing a voluntary movement TMS pulses will be given before each movement This is done to determine whether this type of stimulation interferes with reaction time which would indicated that it interferes with the brain centers executing the reaction to the visual Go-signal
Patients with single ischemic hemispheric lesions at least 12 months after the stroke who initially had a severe paralysis of the arm will be recruited for the study Healthy normal volunteers will also be included in the study A special effort will be made to increase the participation of women and diverse racial groups
Detailed Description:
It has been proposed that recovery of motor function of the paretic arm following stroke is mediated by the ipsilateral intact motor cortex M1 This proposal has not been conclusively tested experimentally and represents an important question in stroke rehabilitation In this protocol we will study the behavioral consequences of transient inactivation of ipsilateral M1 on motor performance of the affected arm in chronic stroke patients with complete and incomplete motor recovery The results from this study will provide fundamental information on the role of ipsilateral M1 in recovery of motor function after chronic stroke
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-N-0078 | None | None | None |