Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005370
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Longitudinal Study of Cortisol and Pulmonary Function
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To conduct a longitudinal study of the relationship between the rate of decline of pulmonary function and measurements of cortisol concentration and excretion in a sample of middle-aged and older men and their wives The study tested the hypothesis that persons whose plasma cortisol concentrations were relatively low albeit within the normal range were predisposed to excessively rapid deterioration of pulmonary function during aging
Detailed Description:
BACKGROUND
It was hoped that the study would provide important insights into the pathogenesis of chronic obstructive pulmonary disease with potential implications for prevention and early therapeutic intervention
DESIGN NARRATIVE
All subjects participating in the Normative Aging Study were recruited for the study at the time of their next scheduled examination Twenty-four hour urinary excretion of free cortisol morning serum cortisol concentration and pre- and post-bronchodilator spirometric indices were measured For the 700 subjects who were recruited during years one and two of the study these measurements were repeated when subjects returned for their next triennial examination in years four and five of the study Respiratory illness and smoking questionnaire data total and differential leukocyte counts and methacholine inhalation challenge test data were also available at both time points The specific aims of the study were to examine 1 the cross-sectional relationship between level of pulmonary function and both morning serum cortisol concentration and 24-hour urinary free cortisol excretion 2 the relationship between the rate of decline of pulmonary function during the follow-up interval and these measurements of cortisol concentration and excretion 3 whether these relationships were modified by smoking history blood total leukocyte count methacholine airway responsiveness or other characteristics and 4 the stability over time of serum cortisol concentration and urinary cortisol excretion in this aging population
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
It was hoped that the study would provide important insights into the pathogenesis of chronic obstructive pulmonary disease with potential implications for prevention and early therapeutic intervention
DESIGN NARRATIVE
All subjects participating in the Normative Aging Study were recruited for the study at the time of their next scheduled examination Twenty-four hour urinary excretion of free cortisol morning serum cortisol concentration and pre- and post-bronchodilator spirometric indices were measured For the 700 subjects who were recruited during years one and two of the study these measurements were repeated when subjects returned for their next triennial examination in years four and five of the study Respiratory illness and smoking questionnaire data total and differential leukocyte counts and methacholine inhalation challenge test data were also available at both time points The specific aims of the study were to examine 1 the cross-sectional relationship between level of pulmonary function and both morning serum cortisol concentration and 24-hour urinary free cortisol excretion 2 the relationship between the rate of decline of pulmonary function during the follow-up interval and these measurements of cortisol concentration and excretion 3 whether these relationships were modified by smoking history blood total leukocyte count methacholine airway responsiveness or other characteristics and 4 the stability over time of serum cortisol concentration and urinary cortisol excretion in this aging population
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL049869 | NIH | None | httpsreporternihgovquickSearchR01HL049869 |