Ignite Creation Date:
2025-12-24 @ 10:40 PM
Ignite Modification Date:
2025-12-25 @ 8:11 PM
Study NCT ID:
NCT04015635
Status:
UNKNOWN
Last Update Posted:
2021-05-14
First Post:
2019-04-30
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The Role of the Immune and Inflammatory Systems in Hypertension
Sponsor:
University of Glasgow
Organization:
Study Overview
Official Title:
A Study of the Roles of the Immune and Inflammatory Systems in Hypertension
Status:
UNKNOWN
Status Verified Date:
2021-05
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To define the cytokine and cellular immune signature of primary hypertension. Cross sectional clinical/laboratory study.
Detailed Description:
Experimental data show the presence of immune and inflammatory systems dysregulation in hypertension. Understanding of the inflammatory and immune nature of hypertension is currently based on studies in rodent models of hypertension, but is supported by human epidemiological and genome wide association studies (GWAS) studies. It is now essential to identify key checkpoints and inflammatory mechanism(s) involved in human hypertension in comprehensive and sufficiently powered studies, which will then be able to guide subsequent in-depth hypothesis-driven mechanistic studies. This approach may provide the basis for future randomized clinical trials (RCTs).
To define the relationships and predictive value of the immune signature of hypertension and clinical phenotypes of hypertension :
* Predictive value of immune signature for blood pressure parameters measured by ambulatory blood pressure measurements (ABPM)
* Predictive value of immune signature for endothelial function assessed by Endo-PAT2000 and flow mediated dilatation (FMD) both complementary non-invasive techniques.
* Predictive value of immune signature for vascular stiffness and central pressure assessed by SphygmoCor
* Predictive value of immune signature for renal function parameters
* Predictive value of immune signature for cognitive function. To define genetic determinants of immune signature of hypertension.
To define the relationships and predictive value of the immune signature of hypertension and clinical phenotypes of hypertension :
* Predictive value of immune signature for blood pressure parameters measured by ambulatory blood pressure measurements (ABPM)
* Predictive value of immune signature for endothelial function assessed by Endo-PAT2000 and flow mediated dilatation (FMD) both complementary non-invasive techniques.
* Predictive value of immune signature for vascular stiffness and central pressure assessed by SphygmoCor
* Predictive value of immune signature for renal function parameters
* Predictive value of immune signature for cognitive function. To define genetic determinants of immune signature of hypertension.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: