Ignite Creation Date:
2024-05-05 @ 9:08 PM
Last Modification Date:
2024-10-26 @ 9:59 AM
Study NCT ID:
NCT00820378
Status:
UNKNOWN
Last Update Posted:
2009-01-14
First Post:
2009-01-08
Brief Title:
The Epidemiology of Aortic Diameter in China
Sponsor:
Zhejiang University
Organization:
Zhejiang University
Study Overview
Official Title:
Epidemiology of Aortic Dimensions in Patients With Clinically Evident Arterial Disease or Cardiovascular Risk Factors
Status:
UNKNOWN
Status Verified Date:
2009-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Aortic aneurysms are the major disease processes affecting the aorta and becoming a relatively common cause of death because of rupture or dissection The most common location for aneurysms is the infrarenal abdominal aorta followed by the ascending thoracic aorta Unlike coronary heart disease the incidence of abdominal aortic aneurysm AAA in the United States and Europe has been increasing and this increase may not be due to higher levels of screening for this condition alone Aortic diameter is central to the diagnosis of aortic aneurysm Furthermore it was demonstrated that non-AAA patients with an enlarged diameter of the infrarenal aortic diameter are also at high risk for all-cause mortality And aortic root dimension was associated with several coronary artery disease CHD risk factors and measures of subclinical disease and was predictive of incident congestive heart failure CHF stroke cardiovascular disease CVD mortality and all-cause mortality but not of incident MI Up to now there are limited studies on the epidemiology of aortic diameter especially in Chinese population
Detailed Description:
The purpose of this study was to analyze the size of the entire aorta at different anatomic levels in a large group of Chinese population with clinically evident arterial disease or cardiovascular risk factors to further explored the risk factors and potential alternative pathomechanisms for the development of aortic dilatation Comprehensive transthoracic M-mode 2-dimensional and Doppler echocardiographic studies will be performed using commercially available equipment The aortic dimensions were assessed at end-diastole at the different levels 1 the annulus 2 the mid-point of the sinuses of Valsalva 3 the sinotubular junction 4 the ascending aorta at the level of its largest diameter 5 the transverse arch 6 the descending aorta posterior to the left atrium and 7 the abdominal aorta just distal to the origin of the renal arteries The extension of dilation is defined as the number of dilated aortic segments The relations among aortic dimensions and clinical characteristics will be assessed by multiple regression analysis The current study was to determine the association of risk factors of CVD and atherosclerosis diseases with aortic dimension in Chinese patients with clinical event atherosclerotic disease or risk factors of atherosclerotic disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None