Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:07 AM
Study NCT ID:
NCT00029809
Status:
COMPLETED
Last Update Posted:
2006-08-18
First Post:
2002-01-23
Brief Title:
Chinese Exercise Modalities in Parkinsons Disease
Sponsor:
National Center for Complementary and Integrative Health NCCIH
Organization:
National Center for Complementary and Integrative Health NCCIH
Study Overview
Official Title:
Chinese Exercise Modalities in Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2006-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will compare the effects of two Chinese and one Western exercise modalities on the signs and symptoms of Parkinsons disease
Detailed Description:
The long-term goal of this project is to study the effects of different exercise modalities on Parkinsons disease PD PD is a disorder whose primary disability stems from motor dysfunction including balance Recent studies have shown that the risk of falling in the elderly can be reduced through the practice of the Chinese complementary and alternative medicine CAM such as Tai Chi Chuan TCC This finding may be highly significant to PD Although a recent report from Emory suggests PD patients can do well with aerobic walk-run exercise training AET it is still unclear whether the potential anti-Parkinsonian effect of such modalities is secondary to improved physical fitness CRF motor control or both CAM interventions such as TCC may offer a unique opportunity to examine these fundamental questions
In PD we hypothesize that exercise training will reduce primary and secondary disability and that some of these changes represent adaptive reprogramming of central motor pathways We will conduct a controlled double-blind 16-week dose-response study of exercise based on caloric expenditure and thus on the cardiorespiratory fitness effects of exercise CRF The treatments will be Qi Gong minimal caloric expenditure TCC low expenditure and walk-cycle AET moderate expenditure
We will examine exercise-induced change in motor control using quantitative measures of motor disability including dynamic gait stability measures We will also examine exercise effects on central and peripheral indices of Parkinsonian motor disability
A caloric dose-response effect of exercise would suggest CRF is a major determinant of the anti-Parkinsonian effects of exercise If the Chinese modalities are as effective or superior to AET however this would suggest that other mechanisms such as change in central motor programming may be playing a role eg relaxation effects reinforcement of central motor programs A better understanding of exercise-induced neural plasticity and motor control would offer a significant and heretofore unexploited rehabilitative potential in PD
In PD we hypothesize that exercise training will reduce primary and secondary disability and that some of these changes represent adaptive reprogramming of central motor pathways We will conduct a controlled double-blind 16-week dose-response study of exercise based on caloric expenditure and thus on the cardiorespiratory fitness effects of exercise CRF The treatments will be Qi Gong minimal caloric expenditure TCC low expenditure and walk-cycle AET moderate expenditure
We will examine exercise-induced change in motor control using quantitative measures of motor disability including dynamic gait stability measures We will also examine exercise effects on central and peripheral indices of Parkinsonian motor disability
A caloric dose-response effect of exercise would suggest CRF is a major determinant of the anti-Parkinsonian effects of exercise If the Chinese modalities are as effective or superior to AET however this would suggest that other mechanisms such as change in central motor programming may be playing a role eg relaxation effects reinforcement of central motor programs A better understanding of exercise-induced neural plasticity and motor control would offer a significant and heretofore unexploited rehabilitative potential in PD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None