Ignite Creation Date:
2024-05-05 @ 11:24 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00023062
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-08-22
Brief Title:
Transcranial Magnetic Stimulation in Parkinsons Disease
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
TMS Measures in Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2003-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation TMS to explore how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease Activity in the motor cortex-the outer part of the brain-will be examined use TMS in patients with Parkinsons disease and in healthy volunteers
Normal volunteers and patients with Parkinsons disease stage I to III 21 years of age and older may be eligible for this study
All participants will have transcranial magnetic stimulation For this procedure an insulated wire coil is placed on the subjects scalp and a brief electrical current is passed through the coil This creates a magnetic pulse that passes into the brain and generates very small electrical currents in the cortex briefly disrupting the function of the brain cells in the stimulated area This may cause muscle twitching or tingling in the face jaw or limb During the stimulation participants will be asked to tense certain muscles slightly or perform other simple actions The electrical activity of the muscle will be recorded on a computer through electrodes taped to the skin over the muscle In most cases the study will last less than 3 hours Participants will also fill out questionnaires about aspects of personality and will be tested for their ability to perform certain cognitive thinking and movement tasks Patients with Parkinsons disease will in addition be administered the Uniform Parkinsons Disease Rating Scale to measure disease severity
Patients will be requested to stop all Parkinsons disease medications 12 hours before the study They may resume medications immediately after the study Patients who so wish may be admitted to the hospital the day or evening before the study while they are off medications and stay there until they feel ready to leave
Normal volunteers and patients with Parkinsons disease stage I to III 21 years of age and older may be eligible for this study
All participants will have transcranial magnetic stimulation For this procedure an insulated wire coil is placed on the subjects scalp and a brief electrical current is passed through the coil This creates a magnetic pulse that passes into the brain and generates very small electrical currents in the cortex briefly disrupting the function of the brain cells in the stimulated area This may cause muscle twitching or tingling in the face jaw or limb During the stimulation participants will be asked to tense certain muscles slightly or perform other simple actions The electrical activity of the muscle will be recorded on a computer through electrodes taped to the skin over the muscle In most cases the study will last less than 3 hours Participants will also fill out questionnaires about aspects of personality and will be tested for their ability to perform certain cognitive thinking and movement tasks Patients with Parkinsons disease will in addition be administered the Uniform Parkinsons Disease Rating Scale to measure disease severity
Patients will be requested to stop all Parkinsons disease medications 12 hours before the study They may resume medications immediately after the study Patients who so wish may be admitted to the hospital the day or evening before the study while they are off medications and stay there until they feel ready to leave
Detailed Description:
Paired pulse transcranial magnetic stimulation TMS provides a measure of the balance of inhibitory and facilitatory activity evokable in the motor cortex Studies in several diverse disorders of basal ganglia outflow and cortical regulation show an alteration in the direction of decreased inhibition or increased facilitation In general these have been quite small data from different interstimulus intervals have been pooled for analysis and therefore disease and state-specific information may have been missed A deeper understanding of what this technique can tell us about pathological and normal cortical regulation requires detailed studies within populations looking for correlations between physiological and clinicalbehavioral variables and large uniform head-to-head comparisons between clinical populations This proposal contains a project that combines the correlational and comparative approaches in Parkinsons disease and healthy individuals Data from this project will then be comparable to future similar studies in other disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-N-0240 | None | None | None |