Ignite Creation Date:
2024-05-05 @ 9:06 PM
Last Modification Date:
2024-10-26 @ 9:59 AM
Study NCT ID:
NCT00819403
Status:
COMPLETED
Last Update Posted:
2020-01-14
First Post:
2009-01-07
Brief Title:
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
The Effects of EzetimibeSimvastatin Versus Simvastatin Alone on Platelet and Inflammatory Biomarkers in Patients With the Metabolic Syndrome
Status:
COMPLETED
Status Verified Date:
2020-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome
Detailed Description:
1 To assess the ex vivo effects of ezetimibesimvastatin ES Vytorin 1040mg and simvastatin S Zocor 40mg on platelet and inflammation biomarkers in patients with documented metabolic syndrome
2 To compare platelet-related effects including PAR-1 receptor inhibition of ES with those of the established anti-platelet agents including aspirin clopidogrel intravenous and oral glycoprotein IIbIIIa inhibitors
3 To determine whether the addition of ezetimibe will yield extra protection beyond lipid modulation in the reduction of inflammation and platelet activation
2 To compare platelet-related effects including PAR-1 receptor inhibition of ES with those of the established anti-platelet agents including aspirin clopidogrel intravenous and oral glycoprotein IIbIIIa inhibitors
3 To determine whether the addition of ezetimibe will yield extra protection beyond lipid modulation in the reduction of inflammation and platelet activation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| MSP-JV IISP 32031 | None | None | None |