Viewing Study NCT00802295



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Study NCT ID: NCT00802295
Status: COMPLETED
Last Update Posted: 2009-09-18
First Post: 2008-12-03

Brief Title: Aneuploidies and Different Stimulation Protocols
Sponsor: Instituto Valenciano de Infertilidad IVI VALENCIA
Organization: Instituto Valenciano de Infertilidad IVI VALENCIA

Study Overview

Official Title: Influence of Ovarian Stimulation and Embryo Aneuploidy
Status: COMPLETED
Status Verified Date: 2009-09
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: None
Brief Summary: Our working hypothesis is that patients undergoing in vitro fertilization IVF with higher response to ovarian stimulation protocols recover a higher number of oocytes and this elevated response could be translated into increased incidence of chromosomally abnormal embryos Our objective is to develop a prospective study on healthy young donors with a previous cycle with high ovarian response 20 oocytes andor E2 levels the day of the hCG injection 3000 pgmL but without developing mild or severe hyperstimulation syndrome After signing a proper written consent these donors would agree to undergo two subsequent stimulation cycles following two different protocols In one cycle the stimulation pattern would be similar to the previous one with elevated response and in another cycle the amount of gonadotropins would be cut down in order to obtain lower ovarian response Oocytes obtained in each cycle would be donated to anonymous recipients and after fertilization embryo quality and chromosomal status of the resulting embryos would be evaluated Preimplantation genetic diagnosis PGD will be performed on day-3 embryos and chromosomes 13 15 16 17 18 21 22 X and Y would be analyzed by fluorescence in situ hybridization FISH
Detailed Description: None

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None