Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00029120
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2002-01-05
Brief Title:
Evaluation of Age- and Alzheimers Disease-Related Memory Disorder
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
MRI Contrast Imaging in the Evaluation and Follow-up of Patients With Memory Disorder and Healthy Controls
Status:
COMPLETED
Status Verified Date:
2008-04-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine how a part of the brain called the hippocampus contributes to memory changes that occur with aging and Alzheimers disease AD
Memory problems are the most important early symptoms of AD The hippocampal region of the brain may be responsible for many age- and AD-related memory disorders This study will use magnetic resonance imaging MRI scans to examine the structure chemical composition and function of the hippocampus in participants with AD participants with mild memory problems participants who are healthy but are at risk for AD and healthy volunteers
Participants in this study will undergo MRI scans of the brain During the MRI participants will perform memory tests to demonstrate hippocampal functioning
Memory problems are the most important early symptoms of AD The hippocampal region of the brain may be responsible for many age- and AD-related memory disorders This study will use magnetic resonance imaging MRI scans to examine the structure chemical composition and function of the hippocampus in participants with AD participants with mild memory problems participants who are healthy but are at risk for AD and healthy volunteers
Participants in this study will undergo MRI scans of the brain During the MRI participants will perform memory tests to demonstrate hippocampal functioning
Detailed Description:
The major focus of the Geriatric Psychiatry Branch GPB is the study of individuals with memory disorders as a result of age or neurodegeneration In particular memory is the most important earliest clinical symptom of Alzheimers disease AD Although the hippocampus may not be a biological determinant of all memories there is a growing body of evidence suggesting that dysfunction of the hippocampus plays an important role in the most common forms of memory disorders This proposal will allow for the application of an array of newly developed magnetic resonance imaging and spectroscopy methods to the study of hippocampal function in these patients Most importantly for the first time structure perfusion and neurochemical composition of the hippocampus in living individuals can be evaluated at high resolution without known risk The study of longitudinal changes in hippocampal function should allow us to understand the contributions that various genotypes eg ApoE4 and abnormalities in cerebrospinal fluid eg A-beta42 and tau play in the development of abnormal hippocampal structure and function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 02-M-0095 | None | None | None |