Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00021879
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2001-08-10
Brief Title:
Visceral Adiposity and CVD Risk in Women
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the influence of total body fat and visceral fat on risk factors of diabetes and cardiovascular disease CVD in black and white women
Detailed Description:
BACKGROUND
Obesity is associated with increased morbidity and mortality Concern about obesity has increased as the prevalence and severity have increased and the age of onset has decreased It has also become clear that the location of fat may play an important role in determining the risk associated with obesity Intra-abdominal fat has been shown to have particularly adverse consequences related to cardiovascular risk factors Of interest is the fact that a number of studies have shown that the impact of overall adiposity differs by race For each unit increase in adiposity blacks appear to have less of an increase in blood pressure and triglycerides and less of a decrease in HDL cholesterol compared to whites This racial difference in the relationship of adiposity to cardiovascular risk status may be related to differences in the distribution of fat It is hypothesized that for a given level and increase in total body fat measured by DEXA black women will have less intra-abdominal fat measured by magnetic resonance imaging
The cohort to be studied is a defined group of black and white women who were initially recruited into the study as children at age nine or 10 years as part of the National Heart Lung and Blood Institute National Growth and Health Study The cohort has been maintained and studied continuously over the past 11 to 12 years with about 75 percent of the original cohort remaining
DESIGN NARRATIVE
Subjects will be studied at age 23 and again at age 25 years At each examination subjects will have measurement of total fat DEXA intra-abdominal fat MRI fasting lipids and lipoproteins insulin and glucose blood pressure and left ventricular mass by echocardiography In addition the timing of pubertal maturation and dietary intake of fat and sucrose will be evaluated as potential determinants of intra-abdominal fat using data previously collected from age nine years to age 22 years Study of this cohort provides a unique opportunity to evaluate whether differences in deposition of intraabdominal fat are related to racial differences in the relationship between adiposity and cardiovascular risk factors It will also allow evaluation of childhood and adolescent determinants of adult intra-abdominal adiposity The results of this investigation may provide insight into the prevention of intra-abdominal fat accumulation and ultimate lowering of risk for cardiovascular disease
Obesity is associated with increased morbidity and mortality Concern about obesity has increased as the prevalence and severity have increased and the age of onset has decreased It has also become clear that the location of fat may play an important role in determining the risk associated with obesity Intra-abdominal fat has been shown to have particularly adverse consequences related to cardiovascular risk factors Of interest is the fact that a number of studies have shown that the impact of overall adiposity differs by race For each unit increase in adiposity blacks appear to have less of an increase in blood pressure and triglycerides and less of a decrease in HDL cholesterol compared to whites This racial difference in the relationship of adiposity to cardiovascular risk status may be related to differences in the distribution of fat It is hypothesized that for a given level and increase in total body fat measured by DEXA black women will have less intra-abdominal fat measured by magnetic resonance imaging
The cohort to be studied is a defined group of black and white women who were initially recruited into the study as children at age nine or 10 years as part of the National Heart Lung and Blood Institute National Growth and Health Study The cohort has been maintained and studied continuously over the past 11 to 12 years with about 75 percent of the original cohort remaining
DESIGN NARRATIVE
Subjects will be studied at age 23 and again at age 25 years At each examination subjects will have measurement of total fat DEXA intra-abdominal fat MRI fasting lipids and lipoproteins insulin and glucose blood pressure and left ventricular mass by echocardiography In addition the timing of pubertal maturation and dietary intake of fat and sucrose will be evaluated as potential determinants of intra-abdominal fat using data previously collected from age nine years to age 22 years Study of this cohort provides a unique opportunity to evaluate whether differences in deposition of intraabdominal fat are related to racial differences in the relationship between adiposity and cardiovascular risk factors It will also allow evaluation of childhood and adolescent determinants of adult intra-abdominal adiposity The results of this investigation may provide insight into the prevention of intra-abdominal fat accumulation and ultimate lowering of risk for cardiovascular disease
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL066430 | NIH | None | httpsreporternihgovquickSearchR01HL066430 |