Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00023075
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-08-22
Brief Title:
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
Status:
COMPLETED
Status Verified Date:
2003-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy H-MRS to define the pathology and progression of primary lateral sclerosis hereditary spastic paraplegia and amyotrophic lateral sclerosis and assess the usefulness of this technique in evaluating patients response to therapy H-MRS will be used to examine metabolic changes in the parts of the brain and spinal cord motor cortex and corticospinal tract involved in movement
Normal volunteers and patients with primary lateral sclerosis hereditary spastic paraplegia or amyotrophic lateral sclerosis between 21 and 65 years of age may be eligible for this study Participants will have up to five H-MRS studies including baseline and follow-up tests For this procedure the subject lies on a stretcher that is moved into a strong magnetic field Earplugs are worn to muffle the loud knocking noise that occurs during switching of radio frequencies The subject will be asked to lie still during each scan for 1 to 8 minutes at a time Total scanning time varies from 20 minutes to 2 hours with most examinations lasting between 45 and 90 minutes Communication with the medical staff is possible at all times during the scan
Normal volunteers and patients with primary lateral sclerosis hereditary spastic paraplegia or amyotrophic lateral sclerosis between 21 and 65 years of age may be eligible for this study Participants will have up to five H-MRS studies including baseline and follow-up tests For this procedure the subject lies on a stretcher that is moved into a strong magnetic field Earplugs are worn to muffle the loud knocking noise that occurs during switching of radio frequencies The subject will be asked to lie still during each scan for 1 to 8 minutes at a time Total scanning time varies from 20 minutes to 2 hours with most examinations lasting between 45 and 90 minutes Communication with the medical staff is possible at all times during the scan
Detailed Description:
Standard MRI imaging of the brain shows no consistent abnormalities in many degenerative disorders with progressive upper motor neuron symptoms including primary lateral sclerosis hereditary spastic paraparesis and amyotrophic lateral sclerosis Nuclear magnetic resonance spectroscopy H-MRS is able to evaluate certain cerebral metabolites that reflect the functioning and integrity of neurons The objective of this protocol is to study metabolic changes in the motor cortex and corticospinal tract using MRS in these disorders to characterize the pathology the progression of the diseases and assess the utility of MRS to follow the response to therapies
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-N-0241 | None | None | None |