Ignite Creation Date:
2024-05-05 @ 8:04 PM
Last Modification Date:
2024-10-26 @ 9:58 AM
Study NCT ID:
NCT00798122
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-08-30
First Post:
2008-11-24
Brief Title:
Study of Women With Acute Coronary Syndromes and Nonobstructive Coronary Artery Disease
Sponsor:
NYU Langone Health
Organization:
NYU Langone Health
Study Overview
Official Title:
Study of Women With Acute Coronary Syndromes and Nonobstructive Coronary Artery Disease
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2024-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
SWAN
Brief Summary:
Approximately 600000 women are treated for acute coronary syndrome ACS annually in the US ACS includes heart attack and a milder form called unstable angina Many of these women have angiograms of which 14-39 show no significant coronary artery disease CAD cholesterol plaque accumulation in arteries of the heart The remaining majority of women with ACS have cholesterol plaque buildup which appears severe enough on angiography to limit blood flow to the heart
It is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again Additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way
Some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound IVUS IVUS involves creating pictures of the artery walls using ultrasound sound waves from within the artery itself In some women without major heart artery blockage heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or IVUS This problem can be found using magnetic resonance imaging MRI which can show blood flow to the heart MRI may also be used to show where the heart has been damaged The pattern of damage could suggest that a heart attack in a woman who has no badly blocked heart arteries happened for one or more of these reasons or another reason
The Study of Women with ACS and Non-obstructive CAD SWAN will use IVUS and MRI to help determine the reasons for heart attacks in women with no major blockages in heart arteries
It is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again Additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way
Some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound IVUS IVUS involves creating pictures of the artery walls using ultrasound sound waves from within the artery itself In some women without major heart artery blockage heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or IVUS This problem can be found using magnetic resonance imaging MRI which can show blood flow to the heart MRI may also be used to show where the heart has been damaged The pattern of damage could suggest that a heart attack in a woman who has no badly blocked heart arteries happened for one or more of these reasons or another reason
The Study of Women with ACS and Non-obstructive CAD SWAN will use IVUS and MRI to help determine the reasons for heart attacks in women with no major blockages in heart arteries
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| DD CSDA 2006066 | OTHER_GRANT | DORIS DUKE CHRTBL FND | None |