Ignite Creation Date:
2024-05-05 @ 8:03 PM
Last Modification Date:
2024-10-26 @ 9:58 AM
Study NCT ID:
NCT00794092
Status:
COMPLETED
Last Update Posted:
2021-06-21
First Post:
2008-11-17
Brief Title:
Magnetic Resonance Imaging of Aortic Aneurysm Instability
Sponsor:
University of Edinburgh
Organization:
University of Edinburgh
Study Overview
Official Title:
Magnetic Resonance Imaging of Aortic Aneurysm Instability
Status:
COMPLETED
Status Verified Date:
2021-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Abdominal aortic aneurysm AAA is a progressive enlargement of the aorta the largest blood vessel in the body It is at risk of bursting when it is usually fatal Currently the risk of the AAA bursting is estimated from its diameter In this study the investigators hope to develop a new type of aneurysm scan involving Magnetic Resonance Imaging MRI It is hoped that this scan will be better at determining which AAAs are at risk of bursting and therefore require an operation to prevent this
Detailed Description:
Abdominal aortic aneurysms AAA have a prevalence of 5 and when ruptured carry a mortality rate of 90 The pathophysiology of AAA encompasses a range of poorly understood biomechanical and biological processes Currently the diameter of the aneurysm is used as a surrogate for the risk of rupture and patients with an aneurysm diameter greater than 55 mm are considered for elective surgical repair However this reliance on a single surrogate measure is too simplistic and does not take into account other physical and biological aspects of the AAA We propose to evaluate the role of inflammation proteolysis and neovascularisation in patients with AAA disease We will compare novel magnetic resonance imaging techniques with blood and tissue measures of inflammation c-reactive protein cytokines macrophage and leucocyte density proteolytic activity matrix metalloproteinases tissue inhibitors of metalloproteinases and neovascularisation vessel density endothelial progenitor cells By comparing findings between patients with symptomatic and asymptomatic disease this study will inform our understanding of the disease process as well as potentially identify risk markers of AAA instability that could be used to follow-up patients with asymptomatic disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None