Ignite Creation Date:
2024-05-05 @ 8:03 PM
Last Modification Date:
2024-10-26 @ 9:58 AM
Study NCT ID:
NCT00795860
Status:
COMPLETED
Last Update Posted:
2017-10-16
First Post:
2008-11-20
Brief Title:
Fatty Acid Metabolism and Insulin Sensitivity the Role of Endurance Exercise
Sponsor:
University of Michigan
Organization:
University of Michigan
Study Overview
Official Title:
Fatty Acid Metabolism and Insulin Sensitivity the Role of Endurance Exercise
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Clearly the effects of diet and exercise are beneficial for obese persons but the underlying mechanisms for the improvements in metabolic health are not completely clear Although mounting evidence suggests that alterations in lipid metabolism in persons with abdominal obesity are associated with a several medical complications including diabetes little is known about the factors responsible for this effect The project in this application is designed to examine how the addition of endurance exercise training to a weight-loss program alters whole-body fatty acid availability uptake and oxidation as well as the expression of cellular factors that regulate these processes In addition we will evaluate whether these alterations are associated with improvements in insulin sensitivity In the end these experiments will provide insight into the cellular and whole-body adaptations in fatty acid metabolism in response to weight-loss and exercise training that may lead to enhancement of insulin sensitivity Identifying relationships between gene expression whole-body fatty acid metabolism and clinical outcome measurements such as insulin sensitivity may lead to improvements in the therapeutic andor the preventative approach to obesity and its co-morbidities
Detailed Description:
Despite robust findings emphasizing the importance of weight-loss and exercise for the prevention and management of insulin resistance and Type 2 diabetes the mechanisms responsible for the improvements in metabolic health are not completely understood Mounting evidence suggests that abnormalities in fatty acid metabolism in persons with abdominal obesity are associated with insulin resistance Alterations in fatty acid mobilization and oxidation may be primary adaptations responsible for the improvements in metabolic health after weight-loss and endurance exercise training We hypothesize that a disparity between muscle fatty acid uptake and oxidation is regulated by the expression of genes and proteins that participate in intracellular transport trafficking and metabolism of fatty acids We believe that alterations in the expression of these factors in response to weight-loss and endurance exercise training will underlie changes in the non-oxidative disposal of fatty acids and thereby improve insulin sensitivity We will determine the effects of weight-loss and exercise training on whole-body fatty acid mobilization and oxidation and the expression of factors that regulate these processes in skeletal muscle In addition we will evaluate how these alterations are associated with improvements in insulin sensitivity These studies will provide insight into how cellular alterations with weight-loss and exercise training and the accompanying changes in whole-body fatty acid metabolism may lead to improvements in metabolic health
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| ADA grant 1-03-JF-10 | OTHER_GRANT | American Diabetes Association | None |