Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00018473
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2001-07-03
Brief Title:
Gene-Environment Interactions in Alzheimers Disease
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Gene-Environment Interactions in Alzheimers Disease
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will create Alzheimer s disease risk profiles for defined combinations of genotypes and environmental exposures This study will carry out a molecular epidemiologic study to identify genetic and environmental risks factors using state of the art techniques The following will be done during the course of this study 1 Recruit both Alzheimers patients and cognitively normal aged veterans 2 Evaluate gene interaction in Alzheimers disease 3 Evaluate gene-environment interactions on the risk of Alzheimers disease These procedures should initially address the question as to whether certain genes either independently or synergistically modify the risk of Alzheimers disease This study will also determine whether certain environmental factors smoking alcohol consumption etc can modify the risk of AD and whether this effect is dependent on certain genetic backgrounds This study will provide information that will be useful in designing therapies develop risk factor profiles to be further tested in future studies designating patients for specific therapies based on genetic factors and providing data and genetic material for future studies This study will also provide a cohort of older and well characterized cognitively normal veterans for prospective genetic epidemiological studies on aging
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None