Ignite Creation Date:
2024-05-05 @ 8:01 PM
Last Modification Date:
2024-10-26 @ 9:57 AM
Study NCT ID:
NCT00783978
Status:
COMPLETED
Last Update Posted:
2012-11-19
First Post:
2008-10-31
Brief Title:
Surfactant Disorders and Chronic Lung Disease
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Surfactant Disorders Associated With Chronic Lung Disease in Children
Status:
COMPLETED
Status Verified Date:
2012-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
APSE
Brief Summary:
Interstitial lung diseases ILD in children represent a heterogeneous group of rare and not well defined disorders Genetic abnormalities of surfactant proteins B SFTPB and more recently C SFTPC have been shown to be related to these pathologies However variability in the lung disease phenotype suggests the involvement of other surfactant-associated genes such as ABCA3 ATP-binding cassette sub-family A member 3 Thus the aim of this project is 1 to assess the prevalence of SFTPC mutation in children with chronic lung diseases 2 to precise clinical and radiological features of children with SFTPC mutation and 3 to identify environmental or genetic factors that may explain the extreme variability of this disease
Detailed Description:
The first stage of this project will be to constitute a clinical radiological biological database of children 1 moth-17 years with severe respiratory distress andor an unexplained chronic ILD Mutations in SFTPC SFTPB and ABCA3 will be further identified by sequencing and documented with using the parents blood samples
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None