Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00015431
Status:
COMPLETED
Last Update Posted:
2019-03-29
First Post:
2001-04-18
Brief Title:
Immune System and Gut Abnormalities in Patients With Common Variable Immunodeficiency With and Without Gastrointestinal Symptoms
Sponsor:
National Institute of Allergy and Infectious Diseases NIAID
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Immune Basis for the Gastrointestinal Complications of Common Variable Immunodeficiency
Status:
COMPLETED
Status Verified Date:
2013-07-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine whether people with common variable immunodeficiency CVID with and without gastrointestinal GI symptoms have gut abnormalities inflammation or loss of function and changes in immune system cells and chemicals in the blood and gut People with CVID have decreased levels of serum immunoglobulin IgG and IgA Patients have sinus lung and other infections and many also have stomach and intestinal problems such as chronic diarrhea inability to absorb nutrition from food and intestinal infections caused by bacteria
CVID patients with gastrointestinal symptoms 10 years of age and older may be eligible for this study CVID patients without gastrointestinal symptoms 18 years of age and older will be enrolled as control subjects Candidates will be screened with a review of their medical records a medical history and physical examination HIV blood test stool sample and hydrogen breath test The breath test measures the amount of hydrogen in the breath after drinking sugar water showing the digestive effects of bacteria in the upper intestine
Participants will be admitted to the NIH Clinical Center for several days to undergo the following procedures
Medical history and physical examination
Blood tests
Urine and stool samples
48-hour stool fat collection measures the amount of undigested fat in the stool to determine the ability of the gut to digest and absorb fat in the diet
D-Xylose absorption test measures the ability of a sugar compound to travel across the lining of the intestine to determine the ability of the gut to absorb nutrients
Upper endoscopy a thin flexible lighted tube is advanced through the mouth to evaluate the esophagus stomach and beginning of the small intestine
Lower endoscopy a thin lighted tube is advanced through the rectum to evaluate the colon
Identification of GI abnormalities associated with changes in immune response in CVID patients will help in developing and testing new treatments for this disease
CVID patients with gastrointestinal symptoms 10 years of age and older may be eligible for this study CVID patients without gastrointestinal symptoms 18 years of age and older will be enrolled as control subjects Candidates will be screened with a review of their medical records a medical history and physical examination HIV blood test stool sample and hydrogen breath test The breath test measures the amount of hydrogen in the breath after drinking sugar water showing the digestive effects of bacteria in the upper intestine
Participants will be admitted to the NIH Clinical Center for several days to undergo the following procedures
Medical history and physical examination
Blood tests
Urine and stool samples
48-hour stool fat collection measures the amount of undigested fat in the stool to determine the ability of the gut to digest and absorb fat in the diet
D-Xylose absorption test measures the ability of a sugar compound to travel across the lining of the intestine to determine the ability of the gut to absorb nutrients
Upper endoscopy a thin flexible lighted tube is advanced through the mouth to evaluate the esophagus stomach and beginning of the small intestine
Lower endoscopy a thin lighted tube is advanced through the rectum to evaluate the colon
Identification of GI abnormalities associated with changes in immune response in CVID patients will help in developing and testing new treatments for this disease
Detailed Description:
Common variable immunodeficiency CVID is a clinically heterogeneous disorder characterized by decreased serum immunoglobulin IgG and IgA levels In addition to chronic or recurrent sinopulmonary infections many patients develop gastrointestinal manifestations that can be disabling or fatal Data suggest that these gut abnormalities have a primary immune basis implicating T cells primarily and are not related to the infectious complications of CVID Currently there is no standard therapy for the associated gastrointestinal disease outside of empiric nutritional intervention for weight loss and non-specific anti-diarrheal agents In addition there is no data about the prevalence of gastrointestinal abnormalities in CVID patients who have no overt gastrointestinal symptoms
The objectives of this study are to characterize the gastrointestinal abnormalities that occur in CVID patients and correlate this with the immunophenotype and cytokine secretion of peripheral blood and lamina propria lymphocytes and monocytes CVID patients with gastrointestinal symptoms of malabsorptionmaldigestion and chronic diarrhea will be targeted for study We will also include a group of patients without gastrointestinal symptoms to provide an estimate of background prevalence and severity of gut abnormalities Subjects will undergo a standard immunologic workup including peripheral blood lymphocyte marker phenotyping and cytokine responses as well as tests of gastrointestinal absorption examination of gut histology by endoscopic biopsy and measurement of gut mucosal cytokine expression Analysis variables will include clinical weight stool frequency results of gut absorption tests laboratory lymphocyte and cytokine assays and gut abnormalities histology scores and specific lesions
The objectives of this study are to characterize the gastrointestinal abnormalities that occur in CVID patients and correlate this with the immunophenotype and cytokine secretion of peripheral blood and lamina propria lymphocytes and monocytes CVID patients with gastrointestinal symptoms of malabsorptionmaldigestion and chronic diarrhea will be targeted for study We will also include a group of patients without gastrointestinal symptoms to provide an estimate of background prevalence and severity of gut abnormalities Subjects will undergo a standard immunologic workup including peripheral blood lymphocyte marker phenotyping and cytokine responses as well as tests of gastrointestinal absorption examination of gut histology by endoscopic biopsy and measurement of gut mucosal cytokine expression Analysis variables will include clinical weight stool frequency results of gut absorption tests laboratory lymphocyte and cytokine assays and gut abnormalities histology scores and specific lesions
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-I-0153 | None | None | None |