Ignite Creation Date:
2025-12-24 @ 10:09 PM
Ignite Modification Date:
2025-12-25 @ 7:45 PM
Study NCT ID:
NCT06938035
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-04-22
First Post:
2024-10-02
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Effect of H.Pylori Infection on Growth Parameters
Sponsor:
Assiut University
Organization:
Study Overview
Official Title:
Effect of H.Pylori Infection on Growth Parameters Of Primary School-aged Children Attending Assuit University Children Hospital
Status:
NOT_YET_RECRUITING
Status Verified Date:
2025-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aimed to assess the effect H.pylori infection on growth parameter Of primary school-aged children Attending Assuit university chilren hospital
Detailed Description:
Undernutrition is caused by insufficient intake, malabsorption, inadequate utilization, and increased demand. There is a positive association between undernutrition and various infections. Chronic exposure to pathogens may affect nutrient absorption and increase nutrient consumption, Among many potential pathogens, chronic Helicobacter pylori (H. pylori) infection may be one cause of undernutrition. H. pylori is a gram-negative, helical, and microaerophilic bacterium, which colonizes gastric epithelial cells' surface. The mode of transmission of H. pylori is not known exactly, but the faecal-oral or oral-oral routes via water or food consumption are thought to be a very common cause. The frequency of H.pylori infection increases with age. The rate of development is higher in societies with low socioeconomic status .
The worldwide prevalence of H. pylori in children varies significantly, from 2.5% in Japan to 34.6% in Ethiopia. Gastric mucosal host factors, as well as environmental and virulence factors of the bacteria, are associated with the clinical outcome of H. pylori infection. it is closely related to chronic gastritis, dyspepsia, and chronic diarrhea. H pylori also remains an important risk factor for duodenal ulcers and duodenal and gastric erosions in children.A number of studies identified correlations of H pylori infection in children with a variety of gastrointestinal diseases including autoimmune gastritis and celiac disease. It also produces different biological effects on hormones such as ghrelin and leptin, which control both growth and appetite, causing changes in appetite and food intake, while causing changes in immunological symptoms and responses .H. pylori is a factor that causes malnutrition and growth retardation, due to malabsorption of nutrients and increased susceptibility to enteric infections, especially in developing countries .
The worldwide prevalence of H. pylori in children varies significantly, from 2.5% in Japan to 34.6% in Ethiopia. Gastric mucosal host factors, as well as environmental and virulence factors of the bacteria, are associated with the clinical outcome of H. pylori infection. it is closely related to chronic gastritis, dyspepsia, and chronic diarrhea. H pylori also remains an important risk factor for duodenal ulcers and duodenal and gastric erosions in children.A number of studies identified correlations of H pylori infection in children with a variety of gastrointestinal diseases including autoimmune gastritis and celiac disease. It also produces different biological effects on hormones such as ghrelin and leptin, which control both growth and appetite, causing changes in appetite and food intake, while causing changes in immunological symptoms and responses .H. pylori is a factor that causes malnutrition and growth retardation, due to malabsorption of nutrients and increased susceptibility to enteric infections, especially in developing countries .
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: