Ignite Creation Date:
2025-12-24 @ 10:08 PM
Ignite Modification Date:
2025-12-28 @ 2:36 AM
Study NCT ID:
NCT00716235
Status:
UNKNOWN
Last Update Posted:
2009-01-16
First Post:
2008-07-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities
Sponsor:
Sheba Medical Center
Organization:
Study Overview
Official Title:
Characterization of Executive Functions and Patterns of Eye Movements in Children With Developmental Disabilities
Status:
UNKNOWN
Status Verified Date:
2009-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to characterize the profile of executive functions and eye movements in several populations of children with developmental disabilities.
Detailed Description:
Abnormal Executive function (EF) profile was considered a major characteristic of Attention deficit / hyperactivity disorder (ADHD) and autism, and is frequently implicated in Developmental coordination disorder (DCD) children as well. The scientific literature implies that the EF profile among these three groups share some common abnormalities, but differ significantly in specific features. Abnormal EF profile may be a core feature of the developmental trajectory of each syndrome.
The fine measurement of eye movements may shed light on the underlying mechanisms of specific disorders, and point to abnormal attention, information processing, or motor organization. Gaze is an important component of social interaction. Eye contact and recognition of other's gaze direction are crucial to empathy assessment.
The current study will embark in the assessment of a wide range of EF in these populations and in a matched control group, as well as their relation to other important parameters such as daily function skills and comorbid neurobehavioral characteristics. It will also assess the pattern of eye movements in response to various visual stimuli in these populations. The main purpose is to characterize the similarities and differences of each of these populations, in terms of EF and eye movements.
Assessment methods:
Clinical parameters:
* Intelligence tests (according to the child's age)
* Communication: DSM-IV, ADOS, Stony Brook questionnaire
* Motor / Coordination: Movement Advanced Battery for Children (M-ABC)
* Attention: Conners Rating Scales - Revised (CRS-R 3rd ed.)
* Sleep: Sleep habits questionnaire
Executive functions will be assessed using the following methods:
* NEPSI-II
* BRIEF questionnaire
* Wisconsin Card Sorting Test
* Tower of Hanoi
Eye movements will be measured using an infra-red video camera produced by ISCAN inc. the following visual stimuli will be presented:
* Human faces presenting various emotions
* Various objects
* Saccade and anti-saccade tasks
The fine measurement of eye movements may shed light on the underlying mechanisms of specific disorders, and point to abnormal attention, information processing, or motor organization. Gaze is an important component of social interaction. Eye contact and recognition of other's gaze direction are crucial to empathy assessment.
The current study will embark in the assessment of a wide range of EF in these populations and in a matched control group, as well as their relation to other important parameters such as daily function skills and comorbid neurobehavioral characteristics. It will also assess the pattern of eye movements in response to various visual stimuli in these populations. The main purpose is to characterize the similarities and differences of each of these populations, in terms of EF and eye movements.
Assessment methods:
Clinical parameters:
* Intelligence tests (according to the child's age)
* Communication: DSM-IV, ADOS, Stony Brook questionnaire
* Motor / Coordination: Movement Advanced Battery for Children (M-ABC)
* Attention: Conners Rating Scales - Revised (CRS-R 3rd ed.)
* Sleep: Sleep habits questionnaire
Executive functions will be assessed using the following methods:
* NEPSI-II
* BRIEF questionnaire
* Wisconsin Card Sorting Test
* Tower of Hanoi
Eye movements will be measured using an infra-red video camera produced by ISCAN inc. the following visual stimuli will be presented:
* Human faces presenting various emotions
* Various objects
* Saccade and anti-saccade tasks
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: