Ignite Creation Date:
2024-05-05 @ 7:56 PM
Last Modification Date:
2024-10-26 @ 9:56 AM
Study NCT ID:
NCT00770237
Status:
COMPLETED
Last Update Posted:
2019-08-19
First Post:
2008-10-07
Brief Title:
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
Sponsor:
University of Maryland Baltimore
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Smokers With and Without Schizophrenia
Status:
COMPLETED
Status Verified Date:
2019-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study we will compare cue-reactivity in smokers with and without schizophrenia and the influence of smoking cues on responding for cigarette puffs under a PR schedule of reinforcement Given the high prevalence of smoking among individuals with schizophrenia understanding some of the environmental factors that serve to maintain nicotine dependence is a critical step in improving smoking cessation treatment outcomes Establishing and validating a laboratory model of cue-elicited responsivity and cigarette self- administration will allow the investigation of the efficacy of anti-craving medications in people with schizophrenia
Specific Aims 1 To compare the effects of smoking versus neutral cues on craving mood and autonomic responsivity in smokers with schizophrenia and smokers without schizophrenia 2 To compare the effects of smoking versus neutral cues on the reinforcing efficacy of tobacco cigarettes in smokers with schizophrenia and smokers without schizophrenia
Outcome Measures During cue trials primary measures include craving TCQ-SF VAS mood mood form VAS and autonomic heart rate blood pressure skin conductance and temperature responsivity During self-administration trials primary measures include breakpoint final ratio completed total number of responses and number of cigarette puffs earned and taken Secondary measures include baseline smoking history mood form TCQ-SF CO FTND and urinary cotinine and 3-hydroxycotinine 3-HC
The ratio of 3-HCcotinine is a phenotypic biomarker of the rate of nicotine metabolism which has been shown to be associated with level of nicotine dependence various smoking behaviors and treatment outcome Ho Tyndale 2007 We will correlate the primary measures with the 3-HCcotinine ratio to explore possible relationships for future study
Specific Aims 1 To compare the effects of smoking versus neutral cues on craving mood and autonomic responsivity in smokers with schizophrenia and smokers without schizophrenia 2 To compare the effects of smoking versus neutral cues on the reinforcing efficacy of tobacco cigarettes in smokers with schizophrenia and smokers without schizophrenia
Outcome Measures During cue trials primary measures include craving TCQ-SF VAS mood mood form VAS and autonomic heart rate blood pressure skin conductance and temperature responsivity During self-administration trials primary measures include breakpoint final ratio completed total number of responses and number of cigarette puffs earned and taken Secondary measures include baseline smoking history mood form TCQ-SF CO FTND and urinary cotinine and 3-hydroxycotinine 3-HC
The ratio of 3-HCcotinine is a phenotypic biomarker of the rate of nicotine metabolism which has been shown to be associated with level of nicotine dependence various smoking behaviors and treatment outcome Ho Tyndale 2007 We will correlate the primary measures with the 3-HCcotinine ratio to explore possible relationships for future study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NIDA 430 | None | None | None |