Ignite Creation Date:
2024-05-05 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 9:56 AM
Study NCT ID:
NCT00768716
Status:
COMPLETED
Last Update Posted:
2019-05-23
First Post:
2008-10-07
Brief Title:
Effect of RaceEthnicity and Genes on Acetaminophen Pharmacokinetics
Sponsor:
Tufts University
Organization:
Tufts University
Study Overview
Official Title:
Effect of RaceEthnicity and Genes on Acetaminophen Pharmacokinetics
Status:
COMPLETED
Status Verified Date:
2019-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Although acetaminophen is the most commonly used nonprescription drug in the USA little is known regarding the influence of genes and raceethnicity on acetaminophen disposition The investigators long-term goal is to understand the causes of differences in acetaminophen disposition between people that are the result of genetic variation and ethnicity and may predispose individuals to a higher risk of acetaminophen hepatotoxicity The aim of this particular study is to measure the rate of elimination of acetaminophen via the 3 main pathways glucuronidation sulfation and oxidation in self-identified White-Americans n100 and African-Americans n100 These rates will then be correlated with selected genetic polymorphisms in genes encoding enzymes involved in acetaminophen metabolism Two main hypotheses will be tested 1 African-Americans eliminate acetaminophen more rapidly by glucuronidation than do White-Americans 2 Elimination via glucuronidation sulfation and oxidation in subjects will be significantly correlated with the presence of polymorphisms in the UGT1A6 SULT1A1 and CYP2E1 genes respectively
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01GM102130 | NIH | None | httpsreporternihgovquickSearchR01GM102130 |
| R01GM061834 | NIH | None | None |