Viewing Study NCT00760994



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Study NCT ID: NCT00760994
Status: COMPLETED
Last Update Posted: 2020-08-10
First Post: 2008-09-25

Brief Title: Reducing Alcohol Use Post-traumatic Stress Disorder PTSD With Cognitive Restructuring Experiential Acceptance
Sponsor: Seattle Institute for Biomedical and Clinical Research
Organization: Seattle Institute for Biomedical and Clinical Research

Study Overview

Official Title: Reducing Alcohol Use PTSD w Cognitive Restructuring Experiential Acceptance
Status: COMPLETED
Status Verified Date: 2020-07
Last Known Status: None
Delayed Posting: No
If Stopped, Why?: Not Stopped
Has Expanded Access: False
If Expanded Access, NCT#: N/A
Has Expanded Access, NCT# Status: N/A
Acronym: COPE
Brief Summary: The purpose of this study is to determine whether an experiential acceptance therapy intervention is effective in the treatment of alcohol dependency and post-traumatic stress disorder PTSD symptoms in individuals who suffer from PTSD
Detailed Description: Alcohol dependence AD afflicts nearly 14 of the population Kessler et al 1994 Kessler et al 1997 Regier et al 1990 and has a chronic and relapsing course Brownell Marlatt Litchenstein Wilson 1986 Negative emotional states have consistently been found to maintain alcohol use disorders AUDs Cooney Litt Morse Bauer Gaupp 1997 Litt Cooney Kadden Gaupp 1990 Rubonis et al 1994 and increase the risk of relapse following AUD treatment Cooney et al 1997 This relationship is particularly robust among individuals with co-morbid psychiatric disorders such as posttraumatic stress disorder PTSD Coffey et al 2002 Sharkansy Brief Peirce Meehan Mannix 1999 Tate Brown Unrod Ramo 2004 Waldrop Back Verduin Brady in press Likewise alcohol use may be maintained by a desire to facilitate or prolong positive emotional states Cooper Frone Russell Mudar 1992 Simpson 2003

Many psychological interventions for AUDs most notably the majority of cognitive-behavioral treatment CBT packages have thus focused on the development of coping skills to prevent relapse in response to such triggers and have been demonstrated to be at least moderately effective in promoting abstinence Miller Wilbourne 2002 However attempts to specify the active ingredients of CBT for AD have been disappointing and most studies examining potential mechanisms of change have failed to find the expected relationships Longabaugh et al 2005 Morgenstern Longabaugh 2000 The lack of empirical evidence substantiating coping skills as a mechanism of change for CBT Morgenstern Longabaugh 2000 may be due in part to the lack of specificity in coping skill interventions Broadly speaking two primary foci of coping skill interventions for AUD are 1 increasing cognitive techniques focused on challenging and changing thought patterns or 2 increasing experiential acceptance by fostering an accepting stance towards internal states such as through urge surfing Kadden et al 1992 These two coping skill approaches cognitive restructuring and experiential acceptance likely lead to reduced alcohol use through different pathways Theoretically experiential acceptance approaches suggest that the mechanism of change in decreasing alcohol use is increased willingness toward internal experience eg emotions thoughts sensations whereas cognitive restructuring approaches suggest that decreased alcohol use results from decreases in negative appraisals brought about by challenging and changing thought patterns However this has yet to be systematically evaluated

Study Oversight

Has Oversight DMC: None
Is a FDA Regulated Drug?: None
Is a FDA Regulated Device?: None
Is an Unapproved Device?: None
Is a PPSD?: None
Is a US Export?: None
Is an FDA AA801 Violation?: None
Secondary IDs
Secondary ID Type Domain Link
R21AA017130 NIH None httpsreporternihgovquickSearchR21AA017130