Ignite Creation Date:
2024-05-05 @ 7:55 PM
Last Modification Date:
2024-10-26 @ 9:56 AM
Study NCT ID:
NCT00765401
Status:
WITHDRAWN
Last Update Posted:
2017-11-24
First Post:
2008-09-30
Brief Title:
An Investigation of the Association Between Helicobacter Pylori Infection and Abdominal Pain in Cystic Fibrosis Patients
Sponsor:
Penn State University
Organization:
Penn State University
Study Overview
Official Title:
An Investigation of the Association Between Helicobacter Pylori Infection and Abdominal Pain in Cystic Fibrosis Patients
Status:
WITHDRAWN
Status Verified Date:
2017-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
No participants enrolled
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cystic fibrosis CF is the most common lethal autosomal recessive disease among Caucasians While the pulmonary disease in CF receives most of the attention gastrointestinal diseases occur in 95 of CF individuals and can contribute to significant morbidity mortality and a decreased quality of life The abdominal pain in CF is usual chronic in nature and the etiology is not usually found despite medical testing for standard causes of abdominal pain Helicobacter pylori Hp is increasingly being recognized as the etiology of peptic ulcer disease and other upper and lower gastrointestinal tract diseases1 The role that Hp plays in CF abdominal pain has not been elucidated
Our long-term goal is to understand relationship between chronic HP infection and abdominal pain in pediatric CF patients
The specific objective of this proposal is to utilize current state-of-the-art testing for HP to determine the prevalence of Hp in our CF patients age 5 and older
The central hypothesis is that Cystic fibrosis subjects with significant abdominal pain will have an increased incidence of Helicobacter pylori as determined by the urea breath test and stool antigen test
The rationale for the proposed research is that once we elucidate a causal relationship between CF patients with abdominal pain and Hp we can begin treatment of this infection to improve quality of life
Our long-term goal is to understand relationship between chronic HP infection and abdominal pain in pediatric CF patients
The specific objective of this proposal is to utilize current state-of-the-art testing for HP to determine the prevalence of Hp in our CF patients age 5 and older
The central hypothesis is that Cystic fibrosis subjects with significant abdominal pain will have an increased incidence of Helicobacter pylori as determined by the urea breath test and stool antigen test
The rationale for the proposed research is that once we elucidate a causal relationship between CF patients with abdominal pain and Hp we can begin treatment of this infection to improve quality of life
Detailed Description:
Abdominal pain and Cystic Fibrosis Cystic fibrosis is the most common lethal autosomal recessive disease among Caucasians CF is caused by a single gene mutation on chromosome 7 which encodes for a membrane protein the cystic fibrosis transmembrane conductance regulator CFTR CFTR channel dysfunction results in progressive pulmonary disease which is the primary cause of the morbidity and mortality associated with the disease Therapies directed to slow the progression of the lung disease have increased the USA median survival to 322 years2 Abdominal complaints are very common among CF patients Littlewood et al reported that 31 of children had regular complaints of abdominal pain3 Ravilly et al performed a retrospective chart review on CF patients referred for treatment to the pain service and those that expired4 They determined that pain was very common in CF and that 19 of the population had chronic complaints of abdominal pain which was third behind chest pain and headaches4 This study likely underestimated the prevalence of abdominal pain in CF as it was evaluating an end stage lung disease group of patients that were frequently not eating and had severe pain from other disease processes ie headaches from hypercarbia andor hypoxia and chest pain from rib fractures
Known causes of CF related abdominal pain are 1 malabsorption due to pancreatic steatorrhea 2 gastroesophageal reflux 3 esophagitis 4 gastritis 5 peptic ulcer disease 6 pancreatitis 7 Crohns disease 8 distal intestinal obstructive syndrome DIOS 9 biliary duct disease including cholocystitis and cholangitis 10 intussception 11 acute or chronic gastrointestinal infection 12 acute appendicitis and 13 constipation Given this long list of potential causes CF patients frequently undergo intensive examinations to determine the etiology of the abdominal pain4 The testing unfortunately does not always reveal the etiology
Helicobacter pylori World-wide Helicobacter pylori Hp is increasingly being recognized as the etiology of peptic ulcer disease and other upper and lower gastrointestinal tract diseases1 With the CF population The role that Hp plays in abdominal pain has not been elucidated Two studies have attempted to look at the epidemiology of Hp in CF however the approach utilized in those studies was determined to be inadequate Johansen et al and Israel et al both attempted to utilize Hp serology to determine the prevalence in a CF population and determined that there was significant cross-reactivity between Hp and Pseudomonas aeruginosa antigens10 11 They concluded that different modes of testing are required if Hp is being evaluated in the CF population To our knowledge there have been no further evaluations of Hp in CF using the newer diagnostic tests available
Testing for Helicobacter pylori Since the isolation of spiral urease-producing Helicobacter pylori bacteria H pylori in 1983 by Drs Marshall and Warren5 a significant body of evidence has accumulated indicating that the bacteria is an important pathogen in upper GI tract of humans 67 The causal relation ship between Hpylori and chronic active gastritis duodenal ulcer and gastric ulcer is well documented 8 9 Methods available for detecting current infection of human stomach by Hp are generally divided into two general types Invasive and Non-invasive
Invasive methods include esophageogastroduodenoscopy EGD with collection of gastric biopsies These biopsies are then examined by one or more detection methods histological examination of stained tissue microbiological culture of the organism or direct detection of urease activity in the tissue for example the CLO test Biopsy based methods are expensive entail greater patient risk and discomfort than non-invasive tests and may give false negative results due to sampling errors when colonization of the gastric mucosa is patchy 6
The non-invasive tests include several serological tests that detect serum antibodies to Hp A positive result with these tests can not distinguish between current infection and past exposure to HP and therefore is not a conclusive indicator of current gastrointestinal colonization
The urea breath test is based on the principal that the urease enzyme is not present in human tissue Urease presence is indicative of a urease producing organism in the stomach which is most likely HP The test has a sensitivity and specificity of 90 and a negative predictive value greater that 95 and a positive predictive value of 9012 A third non-invasive test is the Hp stool antigen test also has a sensitivity and specificity of about 90 and high positive and negative predictive values 9513 Major confounding issues with HP testing are systemic antibiotic exposure which can lead to false negative tests and partial treatment14 This is especially problematic in the CF population who are frequently on systemic antibiotics for chronic suppurative bronchitis Thus as part of the inclusion criteria we will only include subjects who have been off antibiotics for at least 14 days prior to enrollment The CF patients will be allowed to continue nebulized antibiotics and prophylactic dose of Azythromycin and analysis will be performed to determine if this results in false negatives by comparing the results to the stool antigen test
Clinical measures of abdominal pain This study is also designed to determine whether the prevalence of Hp is related to a decreased quality of life which if documented suggests a pathological role of Hp in CF Our objective is to use two validated quality of life instruments in this study The PedsQL Pediatric Quality of Life Inventory and the Gastrointestinal Symptom Rating Scale GSRS15 The PedsQL is a modular instrument for measuring health-related quality of life HRQOL in children and adolescents ages 2 to 18 The PedsQL 40 Generic Core Scales are multidimensional child self-report and parent proxy-report scales developed as the generic core measure to be integrated with the PedsQL Disease-Specific Modules The PedsQL 40 Generic Core Scales consist of 23 items applicable for healthy school and community populations as well as pediatric populations with acute and chronic health conditions The GSRS questionnaire involves 15 items using the Likert scale focusing on gastroesophageal reflux abdominal pain constipation indigestion and diarrhea It uses a scale from1 to 4
Known causes of CF related abdominal pain are 1 malabsorption due to pancreatic steatorrhea 2 gastroesophageal reflux 3 esophagitis 4 gastritis 5 peptic ulcer disease 6 pancreatitis 7 Crohns disease 8 distal intestinal obstructive syndrome DIOS 9 biliary duct disease including cholocystitis and cholangitis 10 intussception 11 acute or chronic gastrointestinal infection 12 acute appendicitis and 13 constipation Given this long list of potential causes CF patients frequently undergo intensive examinations to determine the etiology of the abdominal pain4 The testing unfortunately does not always reveal the etiology
Helicobacter pylori World-wide Helicobacter pylori Hp is increasingly being recognized as the etiology of peptic ulcer disease and other upper and lower gastrointestinal tract diseases1 With the CF population The role that Hp plays in abdominal pain has not been elucidated Two studies have attempted to look at the epidemiology of Hp in CF however the approach utilized in those studies was determined to be inadequate Johansen et al and Israel et al both attempted to utilize Hp serology to determine the prevalence in a CF population and determined that there was significant cross-reactivity between Hp and Pseudomonas aeruginosa antigens10 11 They concluded that different modes of testing are required if Hp is being evaluated in the CF population To our knowledge there have been no further evaluations of Hp in CF using the newer diagnostic tests available
Testing for Helicobacter pylori Since the isolation of spiral urease-producing Helicobacter pylori bacteria H pylori in 1983 by Drs Marshall and Warren5 a significant body of evidence has accumulated indicating that the bacteria is an important pathogen in upper GI tract of humans 67 The causal relation ship between Hpylori and chronic active gastritis duodenal ulcer and gastric ulcer is well documented 8 9 Methods available for detecting current infection of human stomach by Hp are generally divided into two general types Invasive and Non-invasive
Invasive methods include esophageogastroduodenoscopy EGD with collection of gastric biopsies These biopsies are then examined by one or more detection methods histological examination of stained tissue microbiological culture of the organism or direct detection of urease activity in the tissue for example the CLO test Biopsy based methods are expensive entail greater patient risk and discomfort than non-invasive tests and may give false negative results due to sampling errors when colonization of the gastric mucosa is patchy 6
The non-invasive tests include several serological tests that detect serum antibodies to Hp A positive result with these tests can not distinguish between current infection and past exposure to HP and therefore is not a conclusive indicator of current gastrointestinal colonization
The urea breath test is based on the principal that the urease enzyme is not present in human tissue Urease presence is indicative of a urease producing organism in the stomach which is most likely HP The test has a sensitivity and specificity of 90 and a negative predictive value greater that 95 and a positive predictive value of 9012 A third non-invasive test is the Hp stool antigen test also has a sensitivity and specificity of about 90 and high positive and negative predictive values 9513 Major confounding issues with HP testing are systemic antibiotic exposure which can lead to false negative tests and partial treatment14 This is especially problematic in the CF population who are frequently on systemic antibiotics for chronic suppurative bronchitis Thus as part of the inclusion criteria we will only include subjects who have been off antibiotics for at least 14 days prior to enrollment The CF patients will be allowed to continue nebulized antibiotics and prophylactic dose of Azythromycin and analysis will be performed to determine if this results in false negatives by comparing the results to the stool antigen test
Clinical measures of abdominal pain This study is also designed to determine whether the prevalence of Hp is related to a decreased quality of life which if documented suggests a pathological role of Hp in CF Our objective is to use two validated quality of life instruments in this study The PedsQL Pediatric Quality of Life Inventory and the Gastrointestinal Symptom Rating Scale GSRS15 The PedsQL is a modular instrument for measuring health-related quality of life HRQOL in children and adolescents ages 2 to 18 The PedsQL 40 Generic Core Scales are multidimensional child self-report and parent proxy-report scales developed as the generic core measure to be integrated with the PedsQL Disease-Specific Modules The PedsQL 40 Generic Core Scales consist of 23 items applicable for healthy school and community populations as well as pediatric populations with acute and chronic health conditions The GSRS questionnaire involves 15 items using the Likert scale focusing on gastroesophageal reflux abdominal pain constipation indigestion and diarrhea It uses a scale from1 to 4
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None