Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00010478
Status:
COMPLETED
Last Update Posted:
2006-08-18
First Post:
2001-02-02
Brief Title:
Acupuncture and Hypertension
Sponsor:
National Center for Complementary and Integrative Health NCCIH
Organization:
National Center for Complementary and Integrative Health NCCIH
Study Overview
Official Title:
Acupuncture and Hypertension-Efficacy and Mechanisms
Status:
COMPLETED
Status Verified Date:
2006-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Although traditional Chinese medicine advocates the use of acupuncture not only to induce analgesia but also to treat essential hypertension acupunctures postulated antihypertensive efficacy in humans has not been subjected to rigorous Western scientific testing Before advocating acupuncture as an effective complementaryalternative medicine strategy for essential hypertension it is necessary to demonstrate that the beneficial effects of acupuncture are scientifically robust long-lasting and explicable in terms of modern scientific mechanisms In spontaneously hypertensive rats acupuncture-like electrical stimulation of thinly myelinated Group III somatic afferents activates central endorphin naloxone-sensitive pathways that elicit long-lasting decreases in sympathetic nerve activity SNA and blood pressure The ability to record SNA with microelectrodes in conscious humans provides a new opportunity to test this novel mechanistic hypothesis in patients undergoing electroacupuncture a modification of the ancient technique that provides a quantifiable and reproducible stimulus to human skeletal muscle afferents Using a randomized double-blind placebo-controlled design we will test the following major hypotheses Electroacupuncture produces a long-lasting reduction in SNA thereby providing a safe and effective complementary treatment of human hypertension Given the enormous interest in acupuncture by our lay public but the paucity of Western scientific data about its efficacy in cardiovascular disorders our studies in normotensive and hypertensive humans should provide a conceptual framework for deciding whether to accept or reject the large body of Chinese and Russian literature advocating acupuncture as a safe and effective treatment of essential hypertension and other cardiovascular disorders such as heart failure and myocardial ischemia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None