Ignite Creation Date:
2024-05-05 @ 7:53 PM
Last Modification Date:
2024-10-26 @ 9:56 AM
Study NCT ID:
NCT00767065
Status:
UNKNOWN
Last Update Posted:
2008-10-06
First Post:
2008-10-03
Brief Title:
Early Cardiac Computed Tomography CT In Patients Admitted With Acute Chest Pain
Sponsor:
Chelsea and Westminster NHS Foundation Trust
Organization:
Chelsea and Westminster NHS Foundation Trust
Study Overview
Official Title:
The Role of Early X-Ray Cardiac Computed Tomography in Patients Admitted With Acute Chest Pain
Status:
UNKNOWN
Status Verified Date:
2008-09
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EXACCT
Brief Summary:
This is a randomised trial comparing early Cardiac Computed Tomography CCT to current standard practice for diagnosis of acute chest pain in patients at low to intermediate risk of having coronary artery disease CAD in a UK setting We hypothesise that early CCT can reduce length of admission reduce NHS costs and improve quality of life whilst being at least as safe as standard practice
Detailed Description:
Coronary Artery Disease CAD kills more people in the UK than any other condition and causes symptoms of angina chest pain in many more Acute chest pain accounts for approximately 600000 NHS admissions per annum but this includes many other types of chest pain not due to heart problems Examination blood tests and an electrocardiogram ECG are used to try and decide the cause of chest pain
Many patients have a low risk of CAD and can be discharged without further investigation Others are at high risk of CAD and must have further tests such as invasive coronary angiography Unfortunately in many patients the initial tests are equivocal and they are felt to have an intermediate probability of CAD Investigation of symptoms in this group may take place in the in-patient setting warranting a hospital stay of several days or alternatively some investigations may be performed as an out-patient with subsequent time spent on waiting lists This results in extensive use of NHS resources and anxiety for the patients whilst awaiting diagnosis often needlessly as approximately half of patients admitted with acute chest pain are eventually discharged without a cardiac cause found
The new technique of cardiac computed tomography CCT offers rapid non-invasive diagnosis of CAD If disease is detected further investigations can be planned when excluded patients may be safely discharged Detection of clinically insignificant disease will initiate primary preventative strategies but excludes CAD as the cause of acute symptoms We will randomise 250 patients presenting to Chelsea and Westminster Hospital with acute chest pain who have intermediate likelihood of CAD to early CCT or current standard practice We hypothesise that when compared to standard practice early CCT will reduce admission length reduce NHS and other costs and improve quality of life without an increase in adverse events
Many patients have a low risk of CAD and can be discharged without further investigation Others are at high risk of CAD and must have further tests such as invasive coronary angiography Unfortunately in many patients the initial tests are equivocal and they are felt to have an intermediate probability of CAD Investigation of symptoms in this group may take place in the in-patient setting warranting a hospital stay of several days or alternatively some investigations may be performed as an out-patient with subsequent time spent on waiting lists This results in extensive use of NHS resources and anxiety for the patients whilst awaiting diagnosis often needlessly as approximately half of patients admitted with acute chest pain are eventually discharged without a cardiac cause found
The new technique of cardiac computed tomography CCT offers rapid non-invasive diagnosis of CAD If disease is detected further investigations can be planned when excluded patients may be safely discharged Detection of clinically insignificant disease will initiate primary preventative strategies but excludes CAD as the cause of acute symptoms We will randomise 250 patients presenting to Chelsea and Westminster Hospital with acute chest pain who have intermediate likelihood of CAD to early CCT or current standard practice We hypothesise that when compared to standard practice early CCT will reduce admission length reduce NHS and other costs and improve quality of life without an increase in adverse events
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None