Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00017979
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-06-23
Brief Title:
Study of Brain Control of Movement
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Effect of Volitional Inhibition on Cortical Inhibitory Mechanisms
Status:
COMPLETED
Status Verified Date:
2002-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease Normal healthy volunteers between the ages of 18 and 65 years may be eligible to participate
In transcranial magnetic stimulation an insulated wire coil is placed on the subjects scalp or skin Brief electrical currents are passed through the coil creating magnetic pulses that stimulate the brain During the stimulation participants will be asked to tense certain muscles slightly or perform other simple actions The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle In most cases the study will last less than 3 hours
In transcranial magnetic stimulation an insulated wire coil is placed on the subjects scalp or skin Brief electrical currents are passed through the coil creating magnetic pulses that stimulate the brain During the stimulation participants will be asked to tense certain muscles slightly or perform other simple actions The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle In most cases the study will last less than 3 hours
Detailed Description:
The purpose of this study is to investigate the influence of voluntary inhibition of movement using either negative motor imagery or GoNoGo reaction task on cortical inhibitory mechanisms Intracortical inhibition ICI and silent period SP are two major cortical inhibitory mechanisms demonstrated by transcranial magnetic stimulation TMS Alterations in these inhibitory mechanisms have been extensively studied in various situations but the influence of voluntary inhibition has not been elucidated yet In normal volunteers therefore we plan to determine if voluntary inhibition of movement influences these cortical inhibitory mechanisms The primary outcome measures would be any changes in motor evoked potential MEP size and intracortical inhibition ICI parameters
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-N-0200 | None | None | None |