Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00018317
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2001-07-03
Brief Title:
Resistance Training and Diet in Patients With Chronic Renal Failure
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Resistance Training and Diet in Patients With Chronic Renal Failure
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the effects of long-term adherence to a low protein diet LPD of 06 gkg-1d-1 with and without progressive resistance exercise training in patients with impaired renal function on body composition renal function glomerular filtration rate nitrogen balance muscle strength and size and functional capacity The hypothesis is that adherence to a LPD will result in a reduction in skeletal muscle mass and reduced strength and functional capacity while those patients who adhere to the LPD and exercise will demonstrate a similar preservation of renal function but will have greater fat free mass muscle mass and strength The intervention trial will last 18 months in which patients with moderate renal failure will be randomly assigned to one of 4 interventions standard care standard care exercise LPD and LPD with exercise In this way the independent and combined effects of diet and exercise on the progression of renal disease and body composition will be monitored This study will have important implications for the treatment of patients with chronic renal failure New strategies of combining exercise with recommendations of a low protein diet may slow the progression of renal disease and improve strength and functional capacity in these at-risk patients
Detailed Description:
Management of dietary protein intake of the CRF patient represents a critical balance between providing adequate protein to meet nutritional requirements and limiting protein intake in the hope of slowing or abating the progression of CRF A number of studies have demonstrated that reduced dietary protein intake can slow the progression of chronic renal failure Finding effective ways to increase nitrogen retention and decrease urinary nitrogen excretion may help CRF patients maintain a more positive nitrogen balance and lessen the nitrogen load on the kidneys for a given dietary protein intake Our laboratory has demonstrated that in older men and women the consequence of adherence to a low protein diet is an accommodation that results in decreased muscle mass strengthand compromised immune function We have also demonstrated that when healthy free living older men and women consume a weight maintenance diet providing the RDA for protein of 08 gkg-1day-1 for 15 weeks they lose skeletal muscle mass These data clearly indicate that elderly people have an increased need for dietary protein compared to young people Data has also demonstrated that progressive resistance exercise improves nitrogen balance in older healthy individuals as well as in patients with mild to moderate chronic renal failure
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None