Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00014820
Status:
COMPLETED
Last Update Posted:
2015-12-18
First Post:
2001-04-11
Brief Title:
Occupation and Asthma in an Urban Low Income Population
Sponsor:
NYU Langone Health
Organization:
NYU Langone Health
Study Overview
Official Title:
Occupation and Asthma in an Urban Low Income Population
Status:
COMPLETED
Status Verified Date:
2015-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study work-related asthma in a low-income urban population
Detailed Description:
BACKGROUND
Work-related asthma is asthma that is attributable to or is made worse by environmental exposures in the workplace Published estimates of the proportion of adult asthma attributable to occupational factors have varied widely depending on population methodology and definitions from 2 percent to 33 percent Occupational asthma is of great public health importance because it is potentially preventable can cause substantial disability and in some cases is completely curable Among adults in the United States asthma has become a major public health problem with rates most elevated among low income urban African American and Latino sectors of the population and with substantial evidence suggesting potential occupational contributions to the excess rates These important sectors of the US population have however been inadequately represented in the occupational asthma research literature
DESIGN NARRATIVE
This was a case control study of physician-diagnosed asthma occupation industry and workplace environmental exposures designed to evaluate the hypothesis that a substantial component of the asthma burden in a low income urban largely minority population was due to occupational factors The study design addressed a variety of methodologic challenges including healthy worker effects difficulty contacting and recruiting this potentially high risk population large numbers of potential etiologic agents mixed exposures small workplaces and low absolute incidence of occupational asthma
The study population was the catchment population of Bellevue Hospital a general hospital in lower Manhattan New York City with busy ambulatory care services that serve low income working communities Cases and controls were recruited from among outpatients and inpatients at Bellevue Hospital and interviewed face-to-face or by telephone Occupation industry and occupational exposures were determined by questionnaire supplemented by a Job Exposure Matrix Odds ratios ORs of association between asthma and specific industrial occupational and exposure categories controlled for major confounders were estimated The ORs were used to calculate occupation- and industry-specific Attributable Fractions and an overall Population Attributable Fraction of asthma attributable to occupational factors New onset occupational asthma and work-aggravated asthma were investigated separately
Work-related asthma is asthma that is attributable to or is made worse by environmental exposures in the workplace Published estimates of the proportion of adult asthma attributable to occupational factors have varied widely depending on population methodology and definitions from 2 percent to 33 percent Occupational asthma is of great public health importance because it is potentially preventable can cause substantial disability and in some cases is completely curable Among adults in the United States asthma has become a major public health problem with rates most elevated among low income urban African American and Latino sectors of the population and with substantial evidence suggesting potential occupational contributions to the excess rates These important sectors of the US population have however been inadequately represented in the occupational asthma research literature
DESIGN NARRATIVE
This was a case control study of physician-diagnosed asthma occupation industry and workplace environmental exposures designed to evaluate the hypothesis that a substantial component of the asthma burden in a low income urban largely minority population was due to occupational factors The study design addressed a variety of methodologic challenges including healthy worker effects difficulty contacting and recruiting this potentially high risk population large numbers of potential etiologic agents mixed exposures small workplaces and low absolute incidence of occupational asthma
The study population was the catchment population of Bellevue Hospital a general hospital in lower Manhattan New York City with busy ambulatory care services that serve low income working communities Cases and controls were recruited from among outpatients and inpatients at Bellevue Hospital and interviewed face-to-face or by telephone Occupation industry and occupational exposures were determined by questionnaire supplemented by a Job Exposure Matrix Odds ratios ORs of association between asthma and specific industrial occupational and exposure categories controlled for major confounders were estimated The ORs were used to calculate occupation- and industry-specific Attributable Fractions and an overall Population Attributable Fraction of asthma attributable to occupational factors New onset occupational asthma and work-aggravated asthma were investigated separately
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL062621 | NIH | None | httpsreporternihgovquickSearchR01HL062621 |