Ignite Creation Date:
2024-05-05 @ 7:51 PM
Last Modification Date:
2024-10-26 @ 9:55 AM
Study NCT ID:
NCT00755339
Status:
COMPLETED
Last Update Posted:
2019-10-25
First Post:
2008-09-17
Brief Title:
Role of the Sensory Experience in Generating Motor Tics in Tourette Syndrome
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Understanding the Anatomy and Physiology of the Sensory Experience and Its Role in Generating Tics in Tourette Syndrome
Status:
COMPLETED
Status Verified Date:
2016-10-25
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate the sensation that many people with Tourette syndrome TS experience before they have a motor tic It will also test whether blocking the sensation causes the tic to stop
People between 18 and 65 years of age with TS who have at least once tic involving an arm may be eligible for this 3-part study Those enrolled may participate in all parts or in part 1 or part 2 Those who choose to participate in part 3 must first complete part 2 All must stop taking medication for TS and any other medication that may affect the brain for at least 1 week before the study
Part 1
After numbing the skin or muscles of the arm or leg where a pre-tic sensation is experienced the response of the nerves will be tested by asking subjects to rate the strength of the sensation after a pinprick and by stimulating the nerves with small electrical shocks Then over the course of approximately one hour subjects will report pre-tic sensations while their motor tics are counted The onset of each tic will be identified with EMG a test using electrodes on the skin to indicate the activity of the muscles
Part 2
Subjects brain waves are recorded using magnetoencephalography MEG while they are experiencing tics andpre-tic sensory experiences MEG is a test that records magnetic field changes produced by brain activity Subjects sit in a chair under a dome containing magnetic field detectors They watch a clock and report the time a sensory experience starts Tics are recorded with EMG Later a standard MRI of the brain scan using a magnetic field and radio waves is done to see which parts of the brain produced the activity recorded with MEG
Part 3
Repetitive transcranial magnetic stimulation rTMS is used to try to stop the pre-tic sensations For TMS the subject sits in a chair A wire coil is held on the subject s scalp and a brief electrical current is passed through the coil creating a magnetic pulse that stimulates a region of the brain The goal of this stimulation is to reduce the sensory experience that precedes a tic in one region of the body During stimulation the subject hears a click and may feel a pulling sensation on the skin under the coil There may be a twitch in the muscles of the face arm or leg This study uses a pattern of repeated pulses delivered in short bursts Following each train of pulses the effect of the stimulation on sensation will be tested by asking the subject to rate the strength of a pinprick and of a vibration In addition the nerves are stimulated with small shocks to evaluate the effect of the TMS on nerve activity To determine the effect of TMS on the pre-tic sensation subjects are asked to watch a clock and report when they are having a sensory experience The effect on motor tics will be evaluated by using EMG to indicate the tics
People between 18 and 65 years of age with TS who have at least once tic involving an arm may be eligible for this 3-part study Those enrolled may participate in all parts or in part 1 or part 2 Those who choose to participate in part 3 must first complete part 2 All must stop taking medication for TS and any other medication that may affect the brain for at least 1 week before the study
Part 1
After numbing the skin or muscles of the arm or leg where a pre-tic sensation is experienced the response of the nerves will be tested by asking subjects to rate the strength of the sensation after a pinprick and by stimulating the nerves with small electrical shocks Then over the course of approximately one hour subjects will report pre-tic sensations while their motor tics are counted The onset of each tic will be identified with EMG a test using electrodes on the skin to indicate the activity of the muscles
Part 2
Subjects brain waves are recorded using magnetoencephalography MEG while they are experiencing tics andpre-tic sensory experiences MEG is a test that records magnetic field changes produced by brain activity Subjects sit in a chair under a dome containing magnetic field detectors They watch a clock and report the time a sensory experience starts Tics are recorded with EMG Later a standard MRI of the brain scan using a magnetic field and radio waves is done to see which parts of the brain produced the activity recorded with MEG
Part 3
Repetitive transcranial magnetic stimulation rTMS is used to try to stop the pre-tic sensations For TMS the subject sits in a chair A wire coil is held on the subject s scalp and a brief electrical current is passed through the coil creating a magnetic pulse that stimulates a region of the brain The goal of this stimulation is to reduce the sensory experience that precedes a tic in one region of the body During stimulation the subject hears a click and may feel a pulling sensation on the skin under the coil There may be a twitch in the muscles of the face arm or leg This study uses a pattern of repeated pulses delivered in short bursts Following each train of pulses the effect of the stimulation on sensation will be tested by asking the subject to rate the strength of a pinprick and of a vibration In addition the nerves are stimulated with small shocks to evaluate the effect of the TMS on nerve activity To determine the effect of TMS on the pre-tic sensation subjects are asked to watch a clock and report when they are having a sensory experience The effect on motor tics will be evaluated by using EMG to indicate the tics
Detailed Description:
Objectives
We will investigate whether the sensory experience that precedes motor tics in Tourette syndrome is generated in the peripheral nervous system and whether it may result from altered sensory gating and whether it is necessary to generate motor tics
Study Population
We will study 100 subjects Thirty-five individuals with a diagnosis of Tourette syndrome who can describe a sensory experience preceding their tics and 10 who deny a sensory prodrome for a total of 45 subjects We will also study 55 Healthy volunteers ages 18-65
Design A Two-Part Study
Part I MEG recording
We will determine the extent to which CNS responses to tactile and auditory stimuli habituate Subjects will be presented with trains of stimuli repeated 80 times At the end of each of these blocks a questionnaire will ascertain the subject s perception of these stimuli CNS responses to the stimuli will be recorded using MEG and analyzed first for localization and then for amplitude and frequency characteristics Healthy volunteers will be included as a control group
Part II rTMS inhibition
We will test whether the sensory experience is necessary for generating a motor tic We will inhibit the sensory experience using repetitive transcranial magnetic stimulation rTMS over the cortical region identified by prior and ongoing imaging studies in our group Low intensity rTMS will be applied as a control Sensory experiences and motor tics will be recorded before and after rTMS
Staged Study
This will be a staged exploratory study In phase 1 we will study 20 adult subjects for part II Data analysis of this phase will determine whether the procedures are well-tolerated and safe enough to allow for the inclusion of adolescent children ages 14 and older Phase 2 will involve completion of both parts with 20 subjects each
Outcome MeasuresTAB
For part II the outcome measures will be 1 inhibition of the sensory experience and 2 the relationship between inhibition of sensory and motor phenomena For part I the outcome measure will be degree of habituation in TS subjects as compared to that in healthy volunteers
We will investigate whether the sensory experience that precedes motor tics in Tourette syndrome is generated in the peripheral nervous system and whether it may result from altered sensory gating and whether it is necessary to generate motor tics
Study Population
We will study 100 subjects Thirty-five individuals with a diagnosis of Tourette syndrome who can describe a sensory experience preceding their tics and 10 who deny a sensory prodrome for a total of 45 subjects We will also study 55 Healthy volunteers ages 18-65
Design A Two-Part Study
Part I MEG recording
We will determine the extent to which CNS responses to tactile and auditory stimuli habituate Subjects will be presented with trains of stimuli repeated 80 times At the end of each of these blocks a questionnaire will ascertain the subject s perception of these stimuli CNS responses to the stimuli will be recorded using MEG and analyzed first for localization and then for amplitude and frequency characteristics Healthy volunteers will be included as a control group
Part II rTMS inhibition
We will test whether the sensory experience is necessary for generating a motor tic We will inhibit the sensory experience using repetitive transcranial magnetic stimulation rTMS over the cortical region identified by prior and ongoing imaging studies in our group Low intensity rTMS will be applied as a control Sensory experiences and motor tics will be recorded before and after rTMS
Staged Study
This will be a staged exploratory study In phase 1 we will study 20 adult subjects for part II Data analysis of this phase will determine whether the procedures are well-tolerated and safe enough to allow for the inclusion of adolescent children ages 14 and older Phase 2 will involve completion of both parts with 20 subjects each
Outcome MeasuresTAB
For part II the outcome measures will be 1 inhibition of the sensory experience and 2 the relationship between inhibition of sensory and motor phenomena For part I the outcome measure will be degree of habituation in TS subjects as compared to that in healthy volunteers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 08-N-0215 | None | None | None |