Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00013962
Status:
COMPLETED
Last Update Posted:
2005-06-24
First Post:
2001-04-03
Brief Title:
Vitamin D Metabolism and the Williams Syndrome
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
Vitamin D Metabolism and the Williams Syndrome
Status:
COMPLETED
Status Verified Date:
2003-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Williams syndrome is a disease in which supravalvular aortic stenosis an elfin facies mental retardation and other congenital defects are sometimes associated with abnormal vitamin D and calcium metabolism Whereas some patients have been reported to show increased sensitivity to vitamin D or an exaggerated response of serum 25-hydroxyvitamin D 25OHD to administration of vitamin D and to have hypercalcemia caused by increased circulating 125-dihydroxyvitamin D125OH2D in infancy and early childhood most patients have normal calcium metabolism and normal values for circulating 25OHD and 125OH2D We propose to carry out further studies of vitamin D metabolism to elucidate the mechanisms for abnormal vitamin D metabolism We will determine the response of serum 125OH2D to administration of 125OH2D3 Measurement of the 125OH2D in the patients compared to normal subjects will be the primary outcome
Detailed Description:
None
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: