Ignite Creation Date:
2024-05-05 @ 7:49 PM
Last Modification Date:
2024-10-26 @ 9:54 AM
Study NCT ID:
NCT00749281
Status:
COMPLETED
Last Update Posted:
2010-07-08
First Post:
2008-09-08
Brief Title:
Neutrophil Gelatinase-associated Lipocalin Concentration in Coronary Artery Disease
Sponsor:
Cardiovascular Research Society Greece
Organization:
Cardiovascular Research Society Greece
Study Overview
Official Title:
Neutrophil Gelatinase-associated Disease a Potential Biomarker of the Severity of Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2009-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Serum NGAL has been described as a biomarker of neutrophil activation and an inflammatory marker which correlates to obesity and its metabolic complications Since neutrophil activation has been implicated in the pathogenesis of coronary artery disease the investigators hypothesized that serum NGAL levels would be higher in patients with CAD and that serum concentration would correlate with the extent of CAD as documented by coronary angiography serving as a potential biomarker of the severity of CAD
Detailed Description:
Inflammation is considered to play a major role in coronary artery disease CAD which accounts for high morbidity and mortality rates in the western world Several lines of evidence support a role for neutrophils in the development of atherosclerosis and its progression
Neutrophil gelatinase-associated lipocalin NGAL also known as Lipocalin-2 is a 25-kDa secretory glycoprotein that was originally identified in mouse kidney cells and human neutrophil granules This protein has been used as a marker of neutrophil activation in several studies while recently it was found to be an inflammatory marker closely related to obesity and its metabolic complications
Recently lactoferrin a protein which co-localizes with NGAL in the specific granules of human neutrophils has been proposed as a more dynamic marker of neutrophil activation compared to the widely used myeloperoxidase in patients with CAD
In line with the accumulating evidence this study is designed to investigate the relationship between serum NGAL concentration and the presence or the severity of coronary artery disease according to coronary angiography
Neutrophil gelatinase-associated lipocalin NGAL also known as Lipocalin-2 is a 25-kDa secretory glycoprotein that was originally identified in mouse kidney cells and human neutrophil granules This protein has been used as a marker of neutrophil activation in several studies while recently it was found to be an inflammatory marker closely related to obesity and its metabolic complications
Recently lactoferrin a protein which co-localizes with NGAL in the specific granules of human neutrophils has been proposed as a more dynamic marker of neutrophil activation compared to the widely used myeloperoxidase in patients with CAD
In line with the accumulating evidence this study is designed to investigate the relationship between serum NGAL concentration and the presence or the severity of coronary artery disease according to coronary angiography
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None