Ignite Creation Date:
2024-05-05 @ 7:48 PM
Last Modification Date:
2024-10-26 @ 9:54 AM
Study NCT ID:
NCT00746772
Status:
COMPLETED
Last Update Posted:
2010-09-08
First Post:
2008-09-02
Brief Title:
Efficacy of Purslane in Treatment of Oral Lichen Planus
Sponsor:
Qazvin University Of Medical Sciences
Organization:
Qazvin University Of Medical Sciences
Study Overview
Official Title:
Treatment of Oral Lichen Planus Lesions
Status:
COMPLETED
Status Verified Date:
2010-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Oral lichen planus OLP is a chronic inflammatory disease whose prevalence in the general population is 05 -22Oral lesions in OLP are chronic rarely undergo spontaneous remission Patients with OLP had significantly increased risk of oral squamous cell carcinoma irrespective of the clinical type of OLP and therapy there is currently no cure for OLP Previous study demonstrated a decreased antioxidant defence and increased oxidative damage to lipidsDNA and proteins in lichen planus This oxidative modifications point to pathophysiological alterations mainly within the basal cell layers of epidermis and at the dermoepidermal junction Purslane is an excellent source of vitamin AC and E and essential amino acids has been described as a power food of the future because of its high nutritive and antioxidant properties The purpose of the study was to determined the efficacy of Purslane in the treatment of oral lichen planus
Detailed Description:
Oral lichen planus is a chronic common inflammatory disorder affecting stratified squamous epithelia The majority problem of OLP is development of oral squamous cell carcinoma irrespective of the clinical type of OLP and therapy Previous study demonstrated a decreased antioxidant defence and increased oxidative damage to lipids DNA and proteins in lichen planus This oxidative modifications point to pathophysiological alterations mainly within the basal cell layers of epidermis and at the dermoepidermal junction So oxidative stress could be effective in pathogenesis of OLP Purslane is an excellent source of vitamin AC and E and essential amino acids has been described as a power food of the future because of its high nutritive and antioxidant properties Purslane also decreased the level of TNF-α and IL6 that are responsible for up-regulated adhesion molecules in OLP lymphocyte T T cell recruited and retained in sub mucosa through receptors to endothelial adhesion molecule and basal keratinocytes undergo apoptosis The purpose of the study was to determined the efficacy of Purslane in the treatment of oral lichen planus
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None