Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00011440
Status:
COMPLETED
Last Update Posted:
2006-03-23
First Post:
2001-02-20
Brief Title:
Pollutant Altered Allergic Responses
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
Markers of Pollutant Altered Allergic Responses
Status:
COMPLETED
Status Verified Date:
2006-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution We sought to experimental determine this by exposing human volunteers to combustion particles a component of air pollution and then challenge them with an allergen such as ragweed or oak tree pollen Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure
Detailed Description:
To study whether particulates enhance the allergic response we chose the upper airway as a model of allergic inflammation and nasal lavage as a non-invasive method for obtaining samples The nasal cavity is both an excellent model of allergic inflammation and provides an easily accessible site for study We measured inflammatory cells and cytokines in the nasal lavage fluid Our specific hypothesis was that particulate exposure prior to allergen challenge would enhance inflammatory cell recruitment and expression of inflammatory cytokines
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None