Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00011856
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-03-01
Brief Title:
Genetic Analysis of Familial Brain Aneurysms
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Linkage Analysis of Familial Intracranial Aneurysms
Status:
COMPLETED
Status Verified Date:
2002-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will investigate cerebral brain aneurysms and their possible inheritance patterns in families It will try to determine how often brain aneurysms occur in families in which more than one member has had an aneurysm and to find the gene or genes that contribute to their development
People in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study They will undergo the following procedures
Blood will be drawn no more than 3 to 4 tablespoons for research to identify genes that contribute to the development of brain aneurysms
A magnetic resonance angiograph MRA scan will be done to examine a specific brain area where aneurysms typically occur Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities
If a more detailed picture of the brain is needed than can be obtained with MRA a more specific MRA scan will be done using a contrast dye to enhance the images
Patients may be invited to participate in related NIH research studies
People in families in which more than one family member had a cerebral aneurysm are eligible for this 1-day study They will undergo the following procedures
Blood will be drawn no more than 3 to 4 tablespoons for research to identify genes that contribute to the development of brain aneurysms
A magnetic resonance angiograph MRA scan will be done to examine a specific brain area where aneurysms typically occur Magnetic resonance imaging uses a strong magnetic field and radio waves to produce images of the brain and detect abnormalities
If a more detailed picture of the brain is needed than can be obtained with MRA a more specific MRA scan will be done using a contrast dye to enhance the images
Patients may be invited to participate in related NIH research studies
Detailed Description:
This study is designed to explore the genetics of familial cerebral aneurysms Families in which more than one person has had a known cerebral aneurysm will be studied Family histories will be obtained and participants identified who are willing to come to the NIH Clinical Center for an MRAngiograph and venipuncture DNA will be isolated and linkage studies undertaken to identify loci involved in the etiology of familial cerebral aneurysms using standard linkage approaches
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-HG-0101 | None | None | None |