Ignite Creation Date:
2024-05-05 @ 7:47 PM
Last Modification Date:
2024-10-26 @ 9:54 AM
Study NCT ID:
NCT00739817
Status:
UNKNOWN
Last Update Posted:
2009-08-18
First Post:
2008-08-21
Brief Title:
Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide
Sponsor:
Ziv Hospital
Organization:
Ziv Hospital
Study Overview
Official Title:
Screening for Primary Ciliary Dyskinesia Using Nasal Nitric Oxide
Status:
UNKNOWN
Status Verified Date:
2009-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background Primary ciliary dyskinesia PCD is a rare genetic disease characterised by recurrent respiratory infections and subfertility due to dysfunction of cilia brushes of the lining cells Undiagnosed and untreated it can result in an irreversible crippling chronic lung disease The diagnosis of PCD is a difficult one and involves the complex assessment of ciliary structure and function Thus PCD is under diagnosed and appropriate preventative and symptomatic treatment may be denied in many patients In addition the gene responsible for PCD is at present unknown thus preventing pre-natal diagnosis and genetic counseling
Working hypothesis and aims Recently it has become apparent that the evaluation of nasally expired nitric oxide NO constitutes a simple and non-invasive diagnostic method which discriminates between PCD patients PCD carriers and healthy controls at high rate of specificity and sensitivity Testing is simple and last approximately one minute We have recently identified a unique isolated Druze population with high prevalence of PCD The high frequency of disease places this closed community at a high risk of undiagnosed PCD
The aim of this project is to use nasal NO measurement as a screening tool to identify possible undiagnosed cases of PCD and PCD carriers in this high risk Druze population
Working hypothesis and aims Recently it has become apparent that the evaluation of nasally expired nitric oxide NO constitutes a simple and non-invasive diagnostic method which discriminates between PCD patients PCD carriers and healthy controls at high rate of specificity and sensitivity Testing is simple and last approximately one minute We have recently identified a unique isolated Druze population with high prevalence of PCD The high frequency of disease places this closed community at a high risk of undiagnosed PCD
The aim of this project is to use nasal NO measurement as a screening tool to identify possible undiagnosed cases of PCD and PCD carriers in this high risk Druze population
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None