Ignite Creation Date:
2024-05-05 @ 7:45 PM
Last Modification Date:
2024-10-26 @ 9:53 AM
Study NCT ID:
NCT00733629
Status:
WITHDRAWN
Last Update Posted:
2019-10-09
First Post:
2008-08-12
Brief Title:
Study of Endothelial Cells in Patients With Hereditary Haemorrhagic Telangiectasia
Sponsor:
Imperial College London
Organization:
Imperial College London
Study Overview
Official Title:
In Vitro Studies pf Endothelial Cells Derived From HHT Patients
Status:
WITHDRAWN
Status Verified Date:
2019-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Technical reasons- unable to process samples therefore did not recruit
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hereditary Haemorrhagic Telangiectasia HHT also known as Osler-Weber-Rendu Syndrome is an disease that leads to the development of dilated and fragile blood vessels We propose to culture endothelial cells from patients with HHT to culture cells that express the proteins mutated in HHT namely endoglin and ALK-1 We will study the properties of these cells which will involve their growth in different conditions and anticipate that DNA mRNA and proteins will be extracted from these cells for study of cell responses and association with expression levels of endoglin and ALK-1 We hypothesize that these cells which express half-normal endoglin or ALK-1 will show altered protein synthetic differences when compared to normal white blood cells We anticipate that that these findings may help to explain aspects of the HHT disease phenotype
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None