Ignite Creation Date:
2024-05-05 @ 7:45 PM
Last Modification Date:
2024-10-26 @ 9:53 AM
Study NCT ID:
NCT00732199
Status:
COMPLETED
Last Update Posted:
2017-06-28
First Post:
2008-08-07
Brief Title:
Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement NREM Sleep
Sponsor:
VA Office of Research and Development
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Determinants of Age-specific Breathing Instability During Sleep
Status:
COMPLETED
Status Verified Date:
2017-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose for this research protocol was to examine the role of breathing control mechanisms that determine the development of sleep-disordered breathing in the elderly This proposal focused on key factors that contribute to the control of ventilation in elderly adults during sleep The investigators studied the age-specific changes in ventilatory control in older and young adults during NREM sleep
Detailed Description:
Sleep apnea-hypopnea syndrome SAS is a relatively common disorder in the US population with significant adverse health consequences Despite the high prevalence of SAS in elderly individuals the underlying mechanisms have remained elusive Specifically the investigators do not know whether the high prevalence of sleep apnea in older adults is due to increased central breathing instability This proposal focused on investigating age-specific differences in the susceptibility to central breathing instability in adults
This project had the following specific objectives
To determine age-specific changes in the hypocapnic apneic threshold during NREM sleep in elderly vs young individuals
To determine age-specific changes in long-term facilitation during sleep in elderly versus young individuals
Procedure The investigators determined the susceptibility to central breathing instability by mechanically ventilating the subjects during NREM sleep using non-invasive pressure support ventilation The investigators compared the hypocapnic apneic threshold in old age60 years and young age 18-50 years individuals who were healthy The investigators also measured the parameters over a continuum of age from 18 to 89 years
- The investigators investigated whether there was a difference in the susceptibility to long term facilitation of ventilation between young and old healthy individuals in response to episodic hypoxia while maintaining isocapnia
Sleep apnea is very common in older Veterans and is associated with significant cardiovascular complications Greater insight into the pathogenesis will have a positive impact on the health of Veterans suffering from this condition This study furthers the understanding of the pathogenesis of breathing instability leading to sleep-disordered breathing during sleep The investigators anticipate findings will provide a basis for new approaches to prevention and management of SAS in Veterans
This project had the following specific objectives
To determine age-specific changes in the hypocapnic apneic threshold during NREM sleep in elderly vs young individuals
To determine age-specific changes in long-term facilitation during sleep in elderly versus young individuals
Procedure The investigators determined the susceptibility to central breathing instability by mechanically ventilating the subjects during NREM sleep using non-invasive pressure support ventilation The investigators compared the hypocapnic apneic threshold in old age60 years and young age 18-50 years individuals who were healthy The investigators also measured the parameters over a continuum of age from 18 to 89 years
- The investigators investigated whether there was a difference in the susceptibility to long term facilitation of ventilation between young and old healthy individuals in response to episodic hypoxia while maintaining isocapnia
Sleep apnea is very common in older Veterans and is associated with significant cardiovascular complications Greater insight into the pathogenesis will have a positive impact on the health of Veterans suffering from this condition This study furthers the understanding of the pathogenesis of breathing instability leading to sleep-disordered breathing during sleep The investigators anticipate findings will provide a basis for new approaches to prevention and management of SAS in Veterans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None