Ignite Creation Date:
2024-05-05 @ 11:23 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00018421
Status:
COMPLETED
Last Update Posted:
2009-01-21
First Post:
2001-07-03
Brief Title:
Effects of Exercise on Patients With Hemiparetic Stroke
Sponsor:
US Department of Veterans Affairs
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Effects of Exercise on Patients With Hemiparetic Stroke
Status:
COMPLETED
Status Verified Date:
2004-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This randomized trial investigates the hypothesis that regular aerobic exercise training using a task specific gait training modality will improve cardiovascular fitness functional mobility and reduce risk factors for recurrent cardiovascular events in chronic hemiparetic stroke patients when compared to matched controls performing just stretching
Detailed Description:
The aims are to determine whether 6 months progressive graded treadmill training 1 improves cardiovascular fitness levels and reduces the excessive energy demands of hemiparetic gait as defined by oxygen consumption levels based on open circuit spirometry during peak and submaximal exercise ambulation tasks 2 increases free living physical activity measured by portable kinematic recording devices and quantitative in vivo determination of energy expenditure using stable isotopes and 3 improves the cardiovascular-metabolic risk factor profile including measures of key endogenous fibrinolysis regulatory enzymes plasma tissue plasminogen activator t-PA and its main circulating inhibitor PAI-1 fasting lipoprotein lipid profiles blood pressure and oral glucose tolerance and insulin responses Measurements of body composition at baseline and after training will further determine the effects of aerobic exercise training on muscle mass and central obesity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None