Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00014872
Status:
TERMINATED
Last Update Posted:
2023-12-14
First Post:
2001-04-11
Brief Title:
Genetic Epidemiology and Energy Metabolism in Black Girls
Sponsor:
University of New Mexico
Organization:
University of New Mexico
Study Overview
Official Title:
None
Status:
TERMINATED
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
This is not a clinical trial and was inadvertently entered into CTgov
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the role of genes and energy metabolism in the pathogenesis of obesity in adolescent Black girls
Detailed Description:
BACKGROUND
The high prevalence of obesity in African-American AA women is of public health importance since AA women suffer higher mortality from cardiovascular and renal diseases than do white women The reason for their marked susceptibility to obesity remains poorly understood though it is now known that AA women manifest lower resting energy expenditure than white women
DESIGN NARRATIVE
This is a multi-pronged metabolic and genetic epidemiologic study to examine two candidate genes UCP3 and b3AR implicated in energy metabolism A total of 600 African American girls aged 12-15 years will be screened using buccal swabs as a non-invasive method of obtaining DNA to determine their UCP3 genotypes as well as b3AR genotypes An estimated 211 girls will be recruited selected based on their UCP3 genotype for measurements of resting energy expenditure and body composition using dual energy X-ray absorptiometry DEXA in a controlled setting of the Clinical Research Center at the Cincinnati Childrens Hospital Variation in resting energy expenditure will be examined across the genotypes of UCP3 with a large sample The 2x3 design will allow the investigators to examine whether the effects associated with UCP3 variation are due to the UCP3 locus alone or due to the additive effect or interaction between UCP3 and b3AR The study will help to elucidate the relationship between variation in two important candidate genes for energy metabolism UCP3 and b3AR and inter-individual variation in the levels of resting energy expenditure in this very high risk for obesity population
The high prevalence of obesity in African-American AA women is of public health importance since AA women suffer higher mortality from cardiovascular and renal diseases than do white women The reason for their marked susceptibility to obesity remains poorly understood though it is now known that AA women manifest lower resting energy expenditure than white women
DESIGN NARRATIVE
This is a multi-pronged metabolic and genetic epidemiologic study to examine two candidate genes UCP3 and b3AR implicated in energy metabolism A total of 600 African American girls aged 12-15 years will be screened using buccal swabs as a non-invasive method of obtaining DNA to determine their UCP3 genotypes as well as b3AR genotypes An estimated 211 girls will be recruited selected based on their UCP3 genotype for measurements of resting energy expenditure and body composition using dual energy X-ray absorptiometry DEXA in a controlled setting of the Clinical Research Center at the Cincinnati Childrens Hospital Variation in resting energy expenditure will be examined across the genotypes of UCP3 with a large sample The 2x3 design will allow the investigators to examine whether the effects associated with UCP3 variation are due to the UCP3 locus alone or due to the additive effect or interaction between UCP3 and b3AR The study will help to elucidate the relationship between variation in two important candidate genes for energy metabolism UCP3 and b3AR and inter-individual variation in the levels of resting energy expenditure in this very high risk for obesity population
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL066070 | NIH | None | httpsreporternihgovquickSearchR01HL066070 |