Ignite Creation Date:
2024-05-05 @ 7:40 PM
Last Modification Date:
2024-10-26 @ 9:51 AM
Study NCT ID:
NCT00710957
Status:
COMPLETED
Last Update Posted:
2018-07-06
First Post:
2008-07-02
Brief Title:
Vitamin D and Physical Function in Older Adults
Sponsor:
Wake Forest University Health Sciences
Organization:
Wake Forest University Health Sciences
Study Overview
Official Title:
Role of Vitamin D Status on Physical Function and Falls in Adults of Advanced Age
Status:
COMPLETED
Status Verified Date:
2018-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Projections from NHANES III indicate that approximately 12000000 US adults 60 years of age have vitamin D insufficiency serum 25OHD 50 nmolL A growing body of evidence suggests that vitamin D status may be important in biologic processes involved in the maintenance of physical function To test the hypothesis that vitamin D insufficiency is associated with poorer muscle strength and physical performance we propose to evaluate the role of vitamin D status serum 25OHD on physical function and falls in the CHS All Stars cohort a population of advanced age The specific aims are as follows
Specific Aim 1 To describe the prevalence and correlates of vitamin D insufficiency in adults of advanced age
Specific Aim 2 To examine the cross-sectional association between vitamin D status and muscle strength leg and grip strength physical performance 3 m15 ft walk time repeated chair stands and standing balance self-reported physical function mobility ADL and IADL disability and falls
Specific Aim 3 To examine the longitudinal association between vitamin D status at baseline and incident disability mobility ADL and IADL disability over 3 years of follow-up
Research Hypotheses Low vitamin D status 25OHD 50 nmolL will be associated with a lower levels of muscle strength and physical performance b higher levels of self-reported limitations in physical function and falls and c greater odds of incident disability
Specific Aim 1 To describe the prevalence and correlates of vitamin D insufficiency in adults of advanced age
Specific Aim 2 To examine the cross-sectional association between vitamin D status and muscle strength leg and grip strength physical performance 3 m15 ft walk time repeated chair stands and standing balance self-reported physical function mobility ADL and IADL disability and falls
Specific Aim 3 To examine the longitudinal association between vitamin D status at baseline and incident disability mobility ADL and IADL disability over 3 years of follow-up
Research Hypotheses Low vitamin D status 25OHD 50 nmolL will be associated with a lower levels of muscle strength and physical performance b higher levels of self-reported limitations in physical function and falls and c greater odds of incident disability
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None