Ignite Creation Date:
2024-05-05 @ 9:57 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001519
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Oxygen Uptake Kinetics During Recovery From Maximal and Submaximal Exercise
Sponsor:
National Institutes of Health Clinical Center CC
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Oxygen Uptake Kinetics During Recovery From Maximal and Submaximal Exercise
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Measurements of dynamic changes in oxygen uptake VO2 kinetics during recovery from exercise may describe regulatory control of oxygen transport and utilization and have greater reliability and less inherent risk than assessment of maximal oxygen uptake VO2max in patients for whom exercise is limited by pain excessive fatigue dyspnea and motivation The purpose of this pilot study is to evaluate the effect of exercise intensity on the time constant describing changes in VO2 tauVO2 during recovery from one minute of constant work rate exercise Five normal healthy volunteers ages 18 and older will perform a progressive maximal aerobic exercise test using a cycle ergometer to determine VO2max and lactate threshold LT estimated by gas exchange Each subject will also complete a series of maximal constant work rate tests and submaximal constant work rate tests at 80 LT and 50 of the difference between LT and VO2max 50 delta Breath by breath variability and VO2 span will be used to determine the number of constant work rate test repetitions for each subject for each exercise intensity needed to establish confidence in tauVO2 A mean response profile of VO2 recovery kinetics for each exercise intensity will be analyzed using non-linear regression to determine tauVO2 To examine the effect of exercise intensity on tauVO2 one way analysis of variance will be used to determine whether differences exist among maximal and submaximal 80 LT and 50 delta time constants We hypothesize that there will be no significant differences among time constants for VO2 during recovery from maximal and submaximal constant work rate exercise lasting one minute The results of this study are expected to provide increased understanding of the measurement of VO2 kinetics during recovery
Detailed Description:
Measurements of dynamic changes in oxygen uptake VO2 kinetics during recovery from exercise may describe regulatory control of oxygen transport and utilization and have greater reliability and less inherent risk than assessment of maximal oxygen uptake VO2max in patients for whom exercise is limited by pain excessive fatigue dyspnea and motivation The purpose of this pilot study is to evaluate the effect of exercise intensity on the time constant describing changes in VO2 tauVO2 during recovery from one minute of constant work rate exercise Five normal healthy volunteers ages 18 and older will perform a progressive maximal aerobic exercise test using a cycle ergometer to determine VO2max and lactate threshold LT estimated by gas exchange Each subject will also complete a series of maximal constant work rate tests and submaximal constant work rate tests at 80 LT and 50 of the difference between LT and VO2max 50 delta Breath by breath variability and VO2 span will be used to determine the number of constant work rate test repetitions for each subject for each exercise intensity needed to establish confidence in tauVO2 A mean response profile of VO2 recovery kinetics for each exercise intensity will be analyzed using non-linear regression to determine tauVO2 To examine the effect of exercise intensity on tauVO2 one way analysis of variance will be used to determine whether differences exist among maximal and submaximal 80 LT and 50 delta time constants We hypothesize that there will be no significant differences among time constants for VO2 during recovery from maximal and submaximal constant work rate exercise lasting one minute The results of this study are expected to provide increased understanding of the measurement of VO2 kinetics during recovery
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-CC-0098 | None | None | None |