Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00014833
Status:
COMPLETED
Last Update Posted:
2016-04-12
First Post:
2001-04-11
Brief Title:
Life Course Socioeconomic Status Social Context and Cardiovascular Disease
Sponsor:
University of North Carolina Chapel Hill
Organization:
University of North Carolina Chapel Hill
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigate the inverse association between socioeconomic status SES and cardiovascular disease CVD in the Atherosclerosis Risk in Communities ARIC Study cohort
Detailed Description:
BACKGROUND
It is well known that cardiovascular disease is inversely associated with SES However SES may change over time and for socially mobile individuals it is not clear whether the association with cardiovascular disease CVD differs for early life SES vs mid-life SES Another issue is that an individual may have a relatively high income andor wealth but may live in a low SES neighborhood It would be desirable to separate out the effects of individual level vs aggregate level SES Finally there is limited evidence that the association of SES with CVD may vary according to ethnic group The bi-ethnic character of the ARIC population makes it a fertile environment to test this hypothesis
DESIGN NARRATIVE
Mechanisms will be identified which explain the strong inverse association between socioeconomic status SES over the life course and cardiovascular disease morbidity and mortality in the Atherosclerosis Risk in Communities ARIC a bi-ethnic population-based sample of four US communities Health outcomes will include non-invasively measured subclinical cardiovascular disease as well as fatal and non-fatal clinical disease manifestations ascertained over the course of 10 years of follow-up Earlier life course socioeconomic status and measurements of current socioeconomic status and biomedical cardiovascular risk factors will be integrated with geocoded contemporary social environmental exposures to assess their impact on cardiovascular function metabolic impairments allostatic load and subclinical and clinical disease Multilevel analyses will be performed with the goal of identifying pathways by which socioeconomic status is related to cardiovascular disease considering relevant health behavior life styles psychosocial stressorssupport mechanisms chronic infectionchronic inflammatory burden autonomic nervous system dysfunction and sustained metabolic impairments The potential modification of the above associations by the social environment will be addressed by these analyses as well as putative differences by gender and ethnicity
These staged analytic goals are made possible by linking Census-based indicators of the social environment to the rich data resources of the ARIC Study a bi-ethnic community-based sample of men and women aged 45-64 years at the time of their baseline examination in 1987-1989 This cohort was re-examined every three years through January 1999 with ascertainment of SES during childhood early adulthood and in mid-life health-relevant behaviors numerous measurements of risk factors and measures of subclinical cardiovascular disease such as carotid artery wall thickness arterial distensibility retinopathy and lower extremity arterial disease These data as well as validated information on hospital discharge diagnoses and on cause-specific mortality accrued over 10 years of follow-up are available Additional life course information on the members of the ARIC cohort will be collected during Year 1 of the study
It is well known that cardiovascular disease is inversely associated with SES However SES may change over time and for socially mobile individuals it is not clear whether the association with cardiovascular disease CVD differs for early life SES vs mid-life SES Another issue is that an individual may have a relatively high income andor wealth but may live in a low SES neighborhood It would be desirable to separate out the effects of individual level vs aggregate level SES Finally there is limited evidence that the association of SES with CVD may vary according to ethnic group The bi-ethnic character of the ARIC population makes it a fertile environment to test this hypothesis
DESIGN NARRATIVE
Mechanisms will be identified which explain the strong inverse association between socioeconomic status SES over the life course and cardiovascular disease morbidity and mortality in the Atherosclerosis Risk in Communities ARIC a bi-ethnic population-based sample of four US communities Health outcomes will include non-invasively measured subclinical cardiovascular disease as well as fatal and non-fatal clinical disease manifestations ascertained over the course of 10 years of follow-up Earlier life course socioeconomic status and measurements of current socioeconomic status and biomedical cardiovascular risk factors will be integrated with geocoded contemporary social environmental exposures to assess their impact on cardiovascular function metabolic impairments allostatic load and subclinical and clinical disease Multilevel analyses will be performed with the goal of identifying pathways by which socioeconomic status is related to cardiovascular disease considering relevant health behavior life styles psychosocial stressorssupport mechanisms chronic infectionchronic inflammatory burden autonomic nervous system dysfunction and sustained metabolic impairments The potential modification of the above associations by the social environment will be addressed by these analyses as well as putative differences by gender and ethnicity
These staged analytic goals are made possible by linking Census-based indicators of the social environment to the rich data resources of the ARIC Study a bi-ethnic community-based sample of men and women aged 45-64 years at the time of their baseline examination in 1987-1989 This cohort was re-examined every three years through January 1999 with ascertainment of SES during childhood early adulthood and in mid-life health-relevant behaviors numerous measurements of risk factors and measures of subclinical cardiovascular disease such as carotid artery wall thickness arterial distensibility retinopathy and lower extremity arterial disease These data as well as validated information on hospital discharge diagnoses and on cause-specific mortality accrued over 10 years of follow-up are available Additional life course information on the members of the ARIC cohort will be collected during Year 1 of the study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL064142 | NIH | None | httpsreporternihgovquickSearchR01HL064142 |