Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00016731
Status:
COMPLETED
Last Update Posted:
2019-12-17
First Post:
2001-05-31
Brief Title:
Adolescence Puberty and Emotion Regulation
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Adolescence Puberty Hormones and Emotion Regulation An fMRI Study
Status:
COMPLETED
Status Verified Date:
2017-10-18
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to use brain imaging technology to compare how the brains of adolescents and adults are activated during tasks that involve emotional responses
Evidence suggests that adolescents and adults experience activation in similar brain regions when they engage in tasks that involve the processing of emotional stimuli However the degree of task-associated activation may differ between adolescents and adults This study will use functional magnetic resonance imaging fMRI to compare brain activation patterns in adolescents and adults This study will also be used to develop emotion-evoking fMRI tasks to determine whether there are puberty and age-linked components of brain development
Evidence suggests that adolescents and adults experience activation in similar brain regions when they engage in tasks that involve the processing of emotional stimuli However the degree of task-associated activation may differ between adolescents and adults This study will use functional magnetic resonance imaging fMRI to compare brain activation patterns in adolescents and adults This study will also be used to develop emotion-evoking fMRI tasks to determine whether there are puberty and age-linked components of brain development
Detailed Description:
The goal of this project is to use functional magnetic resonance imaging fMRI to compare the degree to which brain regions of adolescents and adults with and without steroid-related endocrine disorders are engaged by tasks involving processing of emotionally salient stimuli In healthy subjects based on developmental continuities in the relevant psychological processes we anticipate considerable similarity across age groups in the topography of brain regions engaged by relevant tasks However we hypothesize that developmental differences in cortico-limbic circuits of adolescents and adults will be reflected in patterns of fMRI activation Specifically we hypothesize in both adults and adolescents that attention and memory tasks involving the processing of emotionally salient stimuli will engage the amygdala cingulate gyrus and association cortex of medialinferior prefrontal cortex and temporal regions Nevertheless height of task-associated activation is hypothesized to differ between adolescents and adults within these regions Moreover prior studies distinguish puberty vs age-related aspects of cognitive development some aspects of attention or memory development relate to changes in chronological age whereas other aspects particularly those involving emotional processes relate to pubertal status Therefore we expect eventually to use emotion-evoking fMRI tasks to test hypotheses on the presence of complementary distinguishable puberty vs age-related components of brain development In patients with endocrine disorders we expect to identify abnormal brain function related to defects in steroidogenesis including in utero hyperandrogenism and hypocortisolism seen in Congenital Adrenal Hyperplasia CAH congenital male hyperandrogenism seen in familial male precocious puberty FMPP and hypercortisolism seen as Cushings Syndrome CS
To meet these initial goals we developed and tested a number of attentionemotion tasks in healthy adults and healthy adolescents tested systematically a few of these tasks in the fMRI including a face-emotion processing task an affective picture- processing task a threat bias task a dot-probe task a reward-related task and tasks probing social processing We are now entering the 2nd phase of the protocol in which we are focusing on endocrine disorders CAH FMPP and CS We hypothesize that both face-emotion processing task an affective picture- processing task will engage the amygdala cingulate gyrus and association cortices of the medialinferior prefrontal and temporal regions differently as a function of time of occurrence severity and type of endocrine abnormalities
To meet these initial goals we developed and tested a number of attentionemotion tasks in healthy adults and healthy adolescents tested systematically a few of these tasks in the fMRI including a face-emotion processing task an affective picture- processing task a threat bias task a dot-probe task a reward-related task and tasks probing social processing We are now entering the 2nd phase of the protocol in which we are focusing on endocrine disorders CAH FMPP and CS We hypothesize that both face-emotion processing task an affective picture- processing task will engage the amygdala cingulate gyrus and association cortices of the medialinferior prefrontal and temporal regions differently as a function of time of occurrence severity and type of endocrine abnormalities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 01-M-0152 | None | None | None |