Ignite Creation Date:
2024-05-05 @ 7:38 PM
Last Modification Date:
2024-10-26 @ 9:51 AM
Study NCT ID:
NCT00707200
Status:
COMPLETED
Last Update Posted:
2010-01-26
First Post:
2008-06-26
Brief Title:
The Cytoadherence in Pediatric Malaria CPM Study
Sponsor:
University Health Network Toronto
Organization:
University Health Network Toronto
Study Overview
Official Title:
Clinical Outcomes in Pediatric Plasmodium Falciparum Malaria According to Host Cytoadherence Factors
Status:
COMPLETED
Status Verified Date:
2009-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CPM
Brief Summary:
The purpose of this study is to determine the importance of key blood group molecules in the clinical outcome of Plasmodium falciparum malaria infection in children
Detailed Description:
Every year nearly 2 million children die from infection with Plasmodium falciparum malaria When red blood cells RBC become infected with malaria a sticky parasite-derived knob protein termed PfEMP-1 erupts on the RBC surfaces PfEMP-1 attaches to several blood group molecules including those found on other RBC on blood vessels and on the cells that normally help to stop bleeding platelets The cellular sticking results in a dangerous interruption in blood flow to vital organs causing brain injury cerebral malaria systemic shock lactic acidosis and death Depending on an individuals inherited blood groups of relevance adhesion may be extensive or limited In the laboratory PfEMP-1 adheres to RBCs via the A or B but not the O antigens of the ABO blood group system and to platelets and blood vessels via platelet glycoprotein IV CD36 and ICAM-1 Consistent with the expected evolutionary advantage of being deficient in these binding targets blood type O and low-expression of CD36 are found more frequently among Africans The Cytoadherence in Pediatric Malaria CPM project is determining the distribution of adhesive blood group molecules in a cohort of 2000 Ugandan children according to the extent of malaria severity and death and thus their ultimate clinical and evolutionary significance in malarial survival This knowledge may serve as the grounds for developing targeted cytoadhesion-interruption therapies in our fight against malaria
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| HS 356 | None | None | None |
| ISBT 777531237 | None | None | None |