Ignite Creation Date:
2024-05-05 @ 11:22 AM
Last Modification Date:
2024-10-26 @ 9:06 AM
Study NCT ID:
NCT00017316
Status:
COMPLETED
Last Update Posted:
2013-02-11
First Post:
2001-06-06
Brief Title:
Thalidomide and SU5416 in Treating Patients With Metastatic Melanoma
Sponsor:
National Cancer Institute NCI
Organization:
National Cancer Institute NCI
Study Overview
Official Title:
A Phase II Pharmacologic and Biologic Study of Escalating Doses of Thalidomide NSC 66847 Administered Orally Once a Day in Combination With a Fixed Dose of SU5416 NSC 696819 in Patients With Metastatic Melanoma
Status:
COMPLETED
Status Verified Date:
2002-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Phase II trial to study the effectiveness of combining thalidomide and SU5416 in treating patients who have metastatic melanoma Thalidomide combined with SU5416 may stop the growth of metastatic melanoma by stopping blood flow to the tumor
Detailed Description:
OBJECTIVES
I Determine the efficacy of thalidomide and SU5416 in patients with metastatic melanoma
II Determine the quantitative and qualitative toxic effects of this regimen in these patients
III Evaluate the pharmacokinetics of this regimen in these patients IV Determine the complete and partial responses and response duration in patients treated with this regimen
V Assess disease-free survival at 6 months of patients treated with this regimen
OUTLINE
Patients receive SU5416 IV over 1 hour twice weekly and oral thalidomide daily beginning 1 day after the first dose of SU5416 Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity
I Determine the efficacy of thalidomide and SU5416 in patients with metastatic melanoma
II Determine the quantitative and qualitative toxic effects of this regimen in these patients
III Evaluate the pharmacokinetics of this regimen in these patients IV Determine the complete and partial responses and response duration in patients treated with this regimen
V Assess disease-free survival at 6 months of patients treated with this regimen
OUTLINE
Patients receive SU5416 IV over 1 hour twice weekly and oral thalidomide daily beginning 1 day after the first dose of SU5416 Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NCI-66 | None | None | None |
| UTHSC-IDD-99-27 | None | None | None |
| SACI-IDD-99-27 | None | None | None |